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Journal of Medicinal Chemistry|May 28, 2004
A bivalent ligand (KDN-21) reveals spinal delta and kappa opioid receptors are organized as heterodimers that give rise to delta(1) and kappa(2) phenotypes. Selective targeting of delta-kappa heterodimersRashmi G Bhushan, Shiv K Sharma, Zhihua Xie, et al.Journal of Medicinal Chemistry|May 28, 2004
Discovery and evaluation of potent P1 aryl heterocycle-based thrombin inhibitorsMary Beth Young, James C Barrow, Kristen L Glass, et al.Journal of Medicinal Chemistry|May 28, 2004
A molecular basis for the selectivity of thiadiazole urea inhibitors with stromelysin-1 and gelatinase-A from generalized born molecular dynamics simulationsRobert C Rizzo, Samuel Toba, Irwin D KuntzJournal of Medicinal Chemistry|May 28, 2004
Synthesis and quantitative structure-activity relationship of hydrazones of N-amino-N'-hydroxyguanidine as electron acceptors for xanthine oxidasePeteris Prusis, Maija Dambrova, Victor Andrianov, et al.Journal of Medicinal Chemistry|May 28, 2004
Synthesis and structure-activity relationships of a novel series of 2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide K(ATP) channel openers: discovery of (-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a potent K(ATP) opener that selectively inhibits spontaneous bladder contractionsWilliam A Carroll, Robert J Altenbach, Hao Bai, et al.Journal of Medicinal Chemistry|May 28, 2004
Chemometric studies on the bactericidal activity of quinolones via an extended VolSurf approachGiovanni Cianchetta, Raimund Mannhold, Gabriele Cruciani, et al.Journal of Medicinal Chemistry|May 28, 2004
Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruziDoron C Greenbaum, Zachary Mackey, Elizabeth Hansell, et al.Journal of Medicinal Chemistry|May 28, 2004
Development of a new type of allosteric modulator of muscarinic receptors: hybrids of the antagonist AF-DX 384 and the hexamethonio derivative W84Marion Mohr, Eberhard Heller, Ameneh Ataie, et al.Journal of Medicinal Chemistry|February 21, 1992
Crystal-structure-based design and synthesis of benz[cd]indole-containing inhibitors of thymidylate synthaseM D Varney, G P Marzoni, C L Palmer, et al.Journal of Medicinal Chemistry|February 21, 1992
N,N'-disubstituted guanidine high-potency sweetenersG W Muller, D E Walters, G E DuBoisPageof 3,137