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Journal of Medicinal Chemistry|November 19, 2021
Synthesis, Characterization, and Preclinical Evaluation of a Small-Molecule Prostate-Specific Membrane Antigen-Targeted Monomethyl Auristatin E ConjugateAleksei E Machulkin, Anastasia A Uspenskaya, Nikolay U Zyk, et al.Journal of Medicinal Chemistry|November 19, 2021
COUPY Coumarins as Novel Mitochondria-Targeted Photodynamic Therapy Anticancer AgentsEnrique Ortega-Forte, Anna Rovira, Albert Gandioso, et al.Journal of Medicinal Chemistry|November 22, 2021
Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 MethyltransferaseSharan K Bagal, Clare Gregson, Daniel H O' Donovan, et al.Journal of Medicinal Chemistry|January 18, 2022
Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP-Deleted CancersChristopher R Smith, Ruth Aranda, Thomas P Bobinski, et al.Journal of Medicinal Chemistry|January 18, 2022
Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione Derivative Inhibits d-Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung Cancer CellsZhangping Xiao, Angelina Osipyan, Shanshan Song, et al.Journal of Medicinal Chemistry|January 19, 2022
In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by AmidinoureasSamantha Ottavi, Sarah M Scarry, John Mosior, et al.Journal of Medicinal Chemistry|December 20, 2021
Development of 3-(4-Chlorophenyl)-1-(phenethyl)urea Analogues as Allosteric Modulators of the Cannabinoid Type-1 Receptor: RTICBM-189 is Brain Penetrant and Attenuates Reinstatement of Cocaine-Seeking BehaviorThuy Nguyen, Thomas F Gamage, David B Finlay, et al.Journal of Medicinal Chemistry|December 21, 2021
Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic ReprogrammingYuwen Sheng, Yuwen Chen, Zhongqiu Zeng, et al.Journal of Medicinal Chemistry|December 21, 2021
Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Nav1.7 for the Treatment of PainGregory L Adams, Parul S Pall, Steven M Grauer, et al.Pageof 3,137