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Journal of Medicinal Chemistry|October 25, 2022
Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological EvaluationYating Liu, Wenxia Liu, Shuai Yu, et al.Journal of Medicinal Chemistry|November 1, 2022
Discovery and Optimization of Indoline-Based Compounds as Dual 5-LOX/sEH Inhibitors: In Vitro and In Vivo Anti-Inflammatory CharacterizationIda Cerqua, Simona Musella, Lukas Klaus Peltner, et al.Journal of Medicinal Chemistry|November 6, 2022
Covalently Conjugated NOD2/TLR7 Agonists Are Potent and Versatile Immune PotentiatorsSamo Guzelj, Matjaž Weiss, Bram Slütter, et al.Journal of Medicinal Chemistry|October 14, 2022
Predicting Regioselectivity of AO, CYP, FMO, and UGT Metabolism Using Quantum Mechanical Simulations and Machine LearningMario Öeren, Peter J Walton, James Suri, et al.Journal of Medicinal Chemistry|October 13, 2022
Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment ScreeningShifali Shishodia, Raymundo Nuñez, Brayden P Strohmier, et al.Journal of Medicinal Chemistry|October 13, 2022
Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5Benjamin Suenkel, Sergio Valente, Clemens Zwergel, et al.Journal of Medicinal Chemistry|October 25, 2022
Discovery of a Highly Potent and Orally Bioavailable STAT3 Dual Phosphorylation Inhibitor for Pancreatic Cancer TreatmentPeng He, Aiwu Bian, Ying Miao, et al.Journal of Medicinal Chemistry|October 24, 2022
Design, Synthesis, and Preclinical Activity in Ovarian Cancer Models of New Phosphanegold(I)-N-heterocyclic Carbene ComplexesAdam A A Sulaiman, Naike Casagrande, Cinzia Borghese, et al.Journal of Medicinal Chemistry|October 26, 2022
Screening of a Halogen-Enriched Fragment Library Leads to Unconventional Binding ModesMarcel Dammann, Jason Stahlecker, Markus O Zimmermann, et al.Journal of Medicinal Chemistry|October 6, 2022
Discovery, Chemistry, and Preclinical Development of Pritelivir, a Novel Treatment Option for Acyclovir-Resistant Herpes Simplex Virus InfectionsAlexander Birkmann, Susanne Bonsmann, Dirk Kropeit, et al.Pageof 3,137