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Journal of Medicinal Chemistry|April 26, 2018
Coupling of an Acyl Migration Prodrug Strategy with Bio-activation To Improve Oral Delivery of the HIV-1 Protease Inhibitor AtazanavirMurugaiah A M Subbaiah, Nicholas A Meanwell, John F Kadow, et al.Journal of Medicinal Chemistry|April 26, 2018
Structure-Guided Design, Synthesis, and Characterization of Next-Generation Meprin β InhibitorsDaniel Ramsbeck, Antje Hamann, Georg Richter, et al.Journal of Medicinal Chemistry|July 24, 2018
Structural Optimization and Characterization of Potent Analgesic Macrocyclic Analogues of Neurotensin (8-13)Marc Sousbie, Mélanie Vivancos, Rebecca L Brouillette, et al.Journal of Medicinal Chemistry|July 24, 2018
Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell GrowthPuneet Saxena, Leda Severi, Matteo Santucci, et al.Journal of Medicinal Chemistry|June 8, 2018
Discovery and Identification of Small Molecules as Methuosis Inducers with in Vivo Antitumor ActivitiesWei Huang, Xihuan Sun, Yunzhan Li, et al.Journal of Medicinal Chemistry|June 8, 2018
Discovery of Novel Pyrazole-Based Selective Aldosterone Synthase (CYP11B2) Inhibitors: A New Template to Coordinate the Heme-Iron Motif of CYP11B2Ryo Sakakibara, Wataru Sasaki, Yuichi Onda, et al.Journal of Medicinal Chemistry|June 12, 2018
Design and Synthesis of Novel and Selective Glycine Transporter-1 (GlyT1) Inhibitors with Memory Enhancing PropertiesVincent J Santora, Theresa A Almos, Richard Barido, et al.Journal of Medicinal Chemistry|May 11, 2018
Discovery of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Management of Rheumatoid ArthritisOzlem Akgul, Lorenzo Di Cesare Mannelli, Daniela Vullo, et al.Journal of Medicinal Chemistry|August 10, 2018
A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660)Christopher N Johnson, Jong Sook Ahn, Ildiko M Buck, et al.Journal of Medicinal Chemistry|August 11, 2018
Tailoring the Substitution Pattern on 1,3,5-Triazine for Targeting Cyclooxygenase-2: Discovery and Structure-Activity Relationship of Triazine-4-Aminophenylmorpholin-3-one Hybrids that Reverse Algesia and Inflammation in Swiss Albino MicePalwinder Singh, Sukhmeet Kaur, Priya Kumari, et al.Pageof 3,137