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Journal of Medicinal Chemistry|October 27, 2021
Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein InteractionDavid Norton, William G Bonnette, James F Callahan, et al.Journal of Medicinal Chemistry|October 25, 2021
Development of a Redox-Sensitive Spermine Prodrug for the Potential Treatment of Snyder Robinson SyndromeMukund P Tantak, Vandana Sekhar, Xianzun Tao, et al.Journal of Medicinal Chemistry|October 29, 2021
Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting Its Protein-Protein InteractionsSara Bobone, Luca Pannone, Barbara Biondi, et al.Journal of Medicinal Chemistry|October 14, 2021
Design of Transmembrane Mimetic Structural Probes to Trap Different Stages of γ-Secretase-Substrate InteractionSanjay Bhattarai, Sujan Devkota, Michael S WolfeJournal of Medicinal Chemistry|November 1, 1986
10-Acetyl-10-hydroxyxantho[2,3-f]tetralin 8-glycosides as angular chromophore analogues of anthracyclines: synthesis, redox properties, microsomal oxygen consumption, and antileukemic evaluationJ W Lown, S M Sondhi, J A PlambeckJournal of Medicinal Chemistry|October 18, 2021
Selection and Identification of Novel Antibacterial Agents against Planktonic Growth and Biofilm Formation of Enterococcus faecalisZhong Chen, Kun Song, Yongpeng Shang, et al.Journal of Medicinal Chemistry|October 19, 2021
Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding CooperativityZhengnan Shen, Kiira Ratia, Laura Cooper, et al.Journal of Medicinal Chemistry|October 6, 2021
Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic DisordersHuji Turdi, Hannguang Chao, Jon J Hangeland, et al.Journal of Medicinal Chemistry|October 6, 2021
Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with In Vivo Efficacy against MRSAYanran Lu, Sandip Vibhute, Linsen Li, et al.Journal of Medicinal Chemistry|October 8, 2021
Novel Electrophilic Warhead Targeting a Triple-Negative Breast Cancer Driver in Live Cells Revealed by "Inverse Drug Discovery"Youlong Fan, Hongfei Si, Zhang Zhang, et al.Pageof 3,137