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Journal of Medicinal Chemistry|July 21, 2022
Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical InteractionsGuozhang Xu, Zhijie Liu, Xinkang Wang, et al.Journal of Medicinal Chemistry|July 22, 2022
Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational PlasticityXianghong Guan, Narsihmulu Cheryala, Rezaul Md Karim, et al.Journal of Medicinal Chemistry|April 22, 2022
Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory EfficacyJin Liu, Lin Yuan, Yong Ruan, et al.Journal of Medicinal Chemistry|March 1, 1987
alpha-Methylproline-containing renin inhibitory peptides: in vivo evaluation in an anesthetized, ganglion-blocked, hog renin infused rat modelS Thaisrivongs, D T Pals, J A Lawson, et al.Journal of Medicinal Chemistry|April 19, 2022
Potent Inhibition of SARS-CoV-2 nsp14 N7-Methyltransferase by Sulfonamide-Based Bisubstrate AnaloguesRostom Ahmed-Belkacem, Marcel Hausdorff, Adrien Delpal, et al.Journal of Medicinal Chemistry|April 19, 2022
Induction of Genes Implicated in Stress Response and Autophagy by a Novel Quinolin-8-yl-nicotinamide QN523 in Pancreatic CancerYuting Kuang, Na Ye, Armita Kyani, et al.Journal of Medicinal Chemistry|April 21, 2022
Discovery of a Novel Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2) and Cyclin-Dependent Kinase 4 (CDK4) Dual Inhibitor for the Treatment of Triple-Negative Breast CancerXiaoyu Chen, Chengxia Shu, Wenqiang Li, et al.Journal of Medicinal Chemistry|April 29, 2022
From Structure Modification to Drug Launch: A Systematic Review of the Ongoing Development of Cyclin-Dependent Kinase Inhibitors for Multiple Cancer TherapyZhenfeng Shi, Lei Tian, Taotao Qiang, et al.Journal of Medicinal Chemistry|April 29, 2022
Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing InhibitorsJonas Lategahn, Hannah L Tumbrink, Carsten Schultz-Fademrecht, et al.Journal of Medicinal Chemistry|July 13, 2022
Identification of Human Alanine-Glyoxylate Aminotransferase Ligands as Pharmacological Chaperones for Variants Associated with Primary Hyperoxaluria Type 1Silvia Grottelli, Giannamaria Annunziato, Gioena Pampalone, et al.Pageof 3,137