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Journal of Medicinal Chemistry|February 8, 2022
γ Peptide Nucleic Acid-Based miR-122 Inhibition Rescues Vascular Endothelial Dysfunction in Mice Fed a High-Fat DietRavinder Reddy Gaddam, Karishma Dhuri, Young-Rae Kim, et al.Journal of Medicinal Chemistry|February 10, 2022
Discovery and Optimization of Highly Selective Inhibitors of CDK5Matthew H Daniels, Goran Malojcic, Susan L Clugston, et al.Journal of Medicinal Chemistry|February 17, 2022
Synthesis and Preclinical Characterization of LY3154885, a Human Dopamine D1 Receptor Positive Allosteric Modulator with an Improved Nonclinical Drug-Drug Interaction Risk ProfileJunliang Hao, James Beck, Xin Zhou, et al.Journal of Medicinal Chemistry|February 21, 2022
Discovery and Structural Optimization of Toddacoumalone Derivatives as Novel PDE4 Inhibitors for the Topical Treatment of PsoriasisZhendong Song, Yi-You Huang, Ke-Qiang Hou, et al.Journal of Medicinal Chemistry|February 24, 2022
Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) InhibitorsChunpu Li, Mingbo Su, Wei Zhu, et al.Journal of Medicinal Chemistry|November 1, 2021
Triglyceride-Mimetic Structure-Gated Prodrug Nanoparticles for Smart Cancer TherapyChutong Tian, Jingjing Guo, Yifan Miao, et al.Journal of Medicinal Chemistry|November 1, 2021
Discovery of Chromane-6-Sulfonamide Derivative as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse AgonistLei Chen, Mei Su, Qiu Jin, et al.Journal of Medicinal Chemistry|January 24, 2022
Neochrysosporazines: Precursor-Directed Biosynthesis Defines a Marine-Derived Fungal Natural Product P-Glycoprotein Inhibitory PharmacophoreAmila Agampodi Dewa, Ahmed H Elbanna, Zeinab G Khalil, et al.Journal of Medicinal Chemistry|January 26, 2022
Structural Optimization and Structure-Activity Relationship Studies of 6,6-Dimethyl-4-(phenylamino)-6H-pyrimido[5,4-b][1,4]oxazin-7(8H)-one Derivatives as A New Class of Potent Inhibitors of Pan-Trk and Their Drug-Resistant MutantsShulei Pan, Liting Zhang, Xinling Luo, et al.Journal of Medicinal Chemistry|January 27, 2022
Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding PoseLingtian Zhang, Marialuisa Moccia, David C Briggs, et al.Pageof 3,137