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Journal of Medicinal Chemistry|January 27, 2022
Illuminating a Dark Kinase: Structure-Guided Design, Synthesis, and Evaluation of a Potent Nek1 Inhibitor and Its Effects on the Embryonic Zebrafish PronephrosGeorg Baumann, Tobias Meckel, Kevin Böhm, et al.Journal of Medicinal Chemistry|February 11, 2022
Chasing a Breath of Fresh Air in Cystic Fibrosis (CF): Therapeutic Potential of Selective HDAC6 Inhibitors to Tackle Multiple Pathways in CF PathophysiologySimona Barone, Emilia Cassese, Antonella Ilenia Alfano, et al.Journal of Medicinal Chemistry|May 1, 1986
Thromboxane synthetase inhibitors and antihypertensive agents. 2. N-[(1H-imidazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones and N-[(1H-1,2,4-triazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones as unique antihypertensive agentsJ B Press, W B Wright, P S Chan, et al.Journal of Medicinal Chemistry|February 2, 2022
Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein InteractionFabio Begnini, Stefan Geschwindner, Patrik Johansson, et al.Journal of Medicinal Chemistry|February 3, 2022
Isolation, Synthesis, and Structure-Activity Relationship Study on Daphnane and Tigliane Diterpenes as HIV Latency-Reversing AgentsAhmed H H El-Desoky, Keisuke Eguchi, Naoki Kishimoto, et al.Journal of Medicinal Chemistry|September 1, 1986
Biologically active derivatives of gossypol: synthesis and antimalarial activities of peri-acylated gossylic nitrilesR E Royer, L M Deck, N M Campos, et al.Journal of Medicinal Chemistry|March 23, 2022
Site-Selective Antibody-Drug Conjugation by a Proximity-Driven S to N Acyl Transfer Reaction on a Therapeutic AntibodyTaeJin Lee, Ju Hwan Kim, Se Jeong Kwon, et al.Journal of Medicinal Chemistry|March 23, 2022
Discovery of SPH5030, a Selective, Potent, and Irreversible Tyrosine Kinase Inhibitor for HER2-Amplified and HER2-Mutant Cancer TreatmentDi Li, Yuanxiang Tu, Kaijun Jin, et al.Journal of Medicinal Chemistry|April 7, 2022
Unraveling the Roles of Protein Kinases in Autophagy: An Update on Small-Molecule Compounds for Targeted TherapyJiahui Fu, Yushang Yang, Lingjuan Zhu, et al.Journal of Medicinal Chemistry|March 30, 2022
Cov_DOX: A Method for Structure Prediction of Covalent Protein-Ligand BindingsLin Wei, Yaru Chen, Jiaqi Liu, et al.Pageof 3,137