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Journal of Medicinal Chemistry|March 31, 2022
Discovery of Thieno[2,3-e]indazole Derivatives as Novel Oral Selective Estrogen Receptor Degraders with Highly Improved Antitumor Effect and Favorable DruggabilityZhengyu Lu, Yangzhi Cao, Dan Zhang, et al.Journal of Medicinal Chemistry|March 29, 2022
Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for "Diabesity"Juan M Decara, Henar Vázquez-Villa, José Brea, et al.Journal of Medicinal Chemistry|March 31, 2022
NMR Molecular Replacement Provides New Insights into Binding Modes to Bromodomains of BRD4 and TRIM24Felix Torres, Reto Walser, Janina Kaderli, et al.Journal of Medicinal Chemistry|March 31, 2022
Development of Novel 191Pt-Labeled Hoechst33258: 191Pt Is More Suitable than 111In for Targeting DNAHonoka Obata, Atsushi B Tsuji, Katsushi Kumata, et al.Journal of Medicinal Chemistry|October 15, 2021
Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation In VivoJ Howard Jones, Zhili Xin, Martin Himmelbauer, et al.Journal of Medicinal Chemistry|October 18, 2021
A Chemical Strategy for Intracellular Arming of an Endogenous Broad-Spectrum Antiviral NucleotideKellan T Passow, Haley S Caldwell, Kiet A Ngo, et al.Journal of Medicinal Chemistry|October 18, 2021
Development of 2-(5,6,7-Trifluoro-1H-Indol-3-yl)-quinoline-5-carboxamide as a Potent, Selective, and Orally Available Inhibitor of Human Androgen Receptor Targeting Its Binding Function-3 for the Treatment of Castration-Resistant Prostate CancerEric Leblanc, Fuqiang Ban, Ayse Derya Cavga, et al.Journal of Medicinal Chemistry|September 18, 2018
Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer ChemotherapyBrandt C Huddle, Edward Grimley, Cameron D Buchman, et al.Journal of Medicinal Chemistry|September 25, 2018
Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu4)Sean R Bollinger, Darren W Engers, Joseph D Panarese, et al.Journal of Medicinal Chemistry|September 25, 2018
Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling PathwayTianyu Wang, Xiaoxing Wu, Changying Guo, et al.Pageof 3,137