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Journal of Medicinal Chemistry|March 18, 2022
Synthesis and Profiling of Highly Selective Inhibitors of Methyltransferase DOT1L Based on Carbocyclic C-NucleosidesPrashant Khirsariya, Patrik Pospíšil, Lukáš Maier, et al.Journal of Medicinal Chemistry|March 1, 2022
Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS MutationsChuan Zhou, Zisheng Fan, Zehui Zhou, et al.Journal of Medicinal Chemistry|March 3, 2022
Discovery of Novel Celastrol-Imidazole Derivatives with Anticancer Activity In Vitro and In VivoNa Li, Manyi Xu, Lulu Zhang, et al.Journal of Medicinal Chemistry|March 3, 2022
Discovery of Potent and Orally Bioavailable Platelet-Derived Growth Factor Receptor (PDGFR) Inhibitors for the Treatment of OsteosarcomaXiaojing Chen, Lu Liu, Peng Liu, et al.Journal of Medicinal Chemistry|March 7, 2022
A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus PoisoningOphélie Da Silva, Nicolas Probst, Christophe Landry, et al.Journal of Medicinal Chemistry|March 9, 2022
Structure-Based Design of High-Affinity Fluorescent Probes for the Neuropeptide Y Y1 ReceptorChristoph Müller, Jakob Gleixner, Maris-Johanna Tahk, et al.Journal of Medicinal Chemistry|March 10, 2022
Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4Min Shao, Xiaojuan Chen, Fang Yang, et al.Journal of Medicinal Chemistry|March 10, 2022
Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's DiseaseSandra Codony, Caterina Pont, Christian Griñán-Ferré, et al.Journal of Medicinal Chemistry|March 10, 2022
Optimization of a Pyrimidinone Series for Selective Inhibition of Ca2+/Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic PainJason A Scott, Monica Soto-Velasquez, Michael P Hayes, et al.Journal of Medicinal Chemistry|March 7, 2022
Target Fishing Reveals a Novel Mechanism of 1,2,4-Oxadiazole Derivatives Targeting Rpn6, a Subunit of 26S ProteasomeZhen Dai, Lu-Yan An, Xiao-Yi Chen, et al.Pageof 3,137