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Journal of Medicinal Chemistry|September 4, 2008
Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an orally efficacious inhibitor of insulin-like growth factor-1 receptor kinase with broad spectrum in vivo antitumor activityUpender Velaparthi, Mark Wittman, Peiying Liu, et al.Journal of Medicinal Chemistry|September 4, 2008
Targeting the ribose and phosphate binding site of p38 mitogen-activated protein (MAP) kinase: synthesis and biological testing of 2-alkylsulfanyl-, 4(5)-aryl-, 5(4)-heteroaryl-substituted imidazolesPierre Koch, Christiane Bäuerlein, Hartmut Jank, et al.Journal of Medicinal Chemistry|September 12, 2008
Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp functionNeva Lazarova, Sami S Zoghbi, Jinsoo Hong, et al.Journal of Medicinal Chemistry|August 20, 2008
Crystal structures of rat vitamin D receptor bound to adamantyl vitamin D analogs: structural basis for vitamin D receptor antagonism and partial agonismMakoto Nakabayashi, Sachiko Yamada, Nobuko Yoshimoto, et al.Journal of Medicinal Chemistry|August 20, 2008
Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acidOliver Werz, Christine Greiner, Andreas Koeberle, et al.Journal of Medicinal Chemistry|August 21, 2008
Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antagonistsShi-Liang Tseng, Ming-Shiu Hung, Chun-Ping Chang, et al.Journal of Medicinal Chemistry|August 22, 2008
Discovery of antimycobacterial spiro-piperidin-4-ones: an atom economic, stereoselective synthesis, and biological interventionRaju Ranjith Kumar, Subbu Perumal, Palaniappan Senthilkumar, et al.Journal of Medicinal Chemistry|August 22, 2008
Phosphate prodrugs derived from N-acetylglucosamine have enhanced chondroprotective activity in explant cultures and represent a new lead in antiosteoarthritis drug discoveryChristopher McGuigan, Michaela Serpi, Rita Bibbo, et al.Journal of Medicinal Chemistry|July 18, 2008
Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolaseJoie Garfunkle, Cyrine Ezzili, Thomas J Rayl, et al.Journal of Medicinal Chemistry|July 18, 2008
A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailabilityThomas E Rawson, Matthias Rüth, Elizabeth Blackwood, et al.Pageof 3,141