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Journal of Medicinal Chemistry|February 5, 2009
Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidateSusan M Westaway, Samantha L Brown, Stephen C M Fell, et al.Journal of Medicinal Chemistry|February 10, 2009
Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analoguesLiuyin Zhang, Charles R Robertson, Brad R Green, et al.Journal of Medicinal Chemistry|February 10, 2009
Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activatorsChi B Vu, Jean E Bemis, Jeremy S Disch, et al.Journal of Medicinal Chemistry|February 10, 2009
Directed discovery of agents targeting the Met tyrosine kinase domain by virtual screeningMegan L Peach, Nelly Tan, Sarah J Choyke, et al.Journal of Medicinal Chemistry|December 4, 2008
Potent, orally bioavailable diazabicyclic small-molecule mimetics of second mitochondria-derived activator of caspasesYuefeng Peng, Haiying Sun, Zaneta Nikolovska-Coleska, et al.Journal of Medicinal Chemistry|December 4, 2008
Design, synthesis, and structure-activity relationship, molecular modeling, and NMR studies of a series of phenyl alkyl ketones as highly potent and selective phosphodiesterase-4 inhibitorsShilong Zheng, Gurpreet Kaur, Huanchen Wang, et al.Journal of Medicinal Chemistry|December 4, 2008
In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivativesSimon Lucas, Ralf Heim, Christina Ries, et al.Journal of Medicinal Chemistry|December 4, 2008
Improving tumor uptake and excretion kinetics of 99mTc-labeled cyclic arginine-glycine-aspartic (RGD) dimers with triglycine linkersJiyun Shi, Lijun Wang, Young-Seung Kim, et al.Journal of Medicinal Chemistry|December 5, 2008
Citrullination of linear and cyclic altered peptide ligands from myelin basic protein (MBP(87-99)) epitope elicits a Th1 polarized response by T cells isolated from multiple sclerosis patients: implications in triggering diseaseGeorge Deraos, Kokona Chatzantoni, Minos-Timotheos Matsoukas, et al.Journal of Medicinal Chemistry|December 5, 2008
Development of 3-phenyltropane analogues with high affinity for the dopamine and serotonin transporters and low affinity for the norepinephrine transporterChunyang Jin, Hernán A Navarro, F Ivy CarrollPageof 3,141