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Journal of Medicinal Chemistry|July 12, 2018
Identification of a Selective, Non-Prostanoid EP2 Receptor Agonist for the Treatment of Glaucoma: Omidenepag and its Prodrug Omidenepag IsopropylRyo Iwamura, Masayuki Tanaka, Eiji Okanari, et al.Journal of Medicinal Chemistry|July 14, 2018
The Design, Synthesis, and Characterizations of Spore Germination Inhibitors Effective against an Epidemic Strain of Clostridium difficileShiv K Sharma, Christopher Yip, Emilio Xavier Esposito, et al.Journal of Medicinal Chemistry|July 14, 2018
Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315Clarissa G Jakob, Anup K Upadhyay, Pamela L Donner, et al.Journal of Medicinal Chemistry|July 15, 2018
Design and Synthesis of Natural Product Inspired Libraries Based on the Three-Dimensional (3D) Cedrane Scaffold: Toward the Exploration of 3D Biological SpaceFatemeh Mazraati Tajabadi, Rebecca H Pouwer, Miaomiao Liu, et al.Journal of Medicinal Chemistry|July 11, 2018
Selectivity Challenges in Docking Screens for GPCR Targets and AntitargetsDahlia R Weiss, Joel Karpiak, Xi-Ping Huang, et al.Journal of Medicinal Chemistry|July 11, 2018
Optimizing a Weakly Binding Fragment into a Potent RORγt Inverse Agonist with Efficacy in an in Vivo Inflammation ModelDavid A Carcache, Anna Vulpetti, Joerg Kallen, et al.Journal of Medicinal Chemistry|June 20, 2018
Discovery of the Human Immunodeficiency Virus Type 1 (HIV-1) Attachment Inhibitor Temsavir and Its Phosphonooxymethyl Prodrug FostemsavirTao Wang, Yasu Ueda, Zhongxing Zhang, et al.Journal of Medicinal Chemistry|June 20, 2018
Where Do Recent Small Molecule Clinical Development Candidates Come From?Dean G Brown, Jonas BoströmJournal of Medicinal Chemistry|June 21, 2018
Development of New Photoswitchable Azobenzene Based γ-Aminobutyric Acid (GABA) Uptake Inhibitors with Distinctly Enhanced Potency upon PhotoactivationToni Lutz, Thomas Wein, Georg Höfner, et al.Journal of Medicinal Chemistry|June 22, 2018
Discovery and Optimization of 2-Amino-4-methylquinazoline Derivatives as Highly Potent Phosphatidylinositol 3-Kinase Inhibitors for Cancer TreatmentSongwen Lin, Chunyang Wang, Ming Ji, et al.Pageof 3,141