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Journal of Medicinal Chemistry|July 26, 2016
Discovery of a Highly Potent, Selective, and Orally Bioavailable Macrocyclic Inhibitor of Blood Coagulation Factor VIIa-Tissue Factor ComplexXiaojun Zhang, Peter W Glunz, James A Johnson, et al.Journal of Medicinal Chemistry|July 20, 2016
Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung CancersGérald Lelais, Robert Epple, Thomas H Marsilje, et al.Journal of Medicinal Chemistry|July 3, 1998
Structure-activity relationship studies of novel carbocyclic influenza neuraminidase inhibitorsC U Kim, W Lew, M A Williams, et al.Journal of Medicinal Chemistry|July 3, 1998
New chemical descriptors relevant for the design of biologically active peptides. A multivariate characterization of 87 amino acidsM Sandberg, L Eriksson, J Jonsson, et al.Journal of Medicinal Chemistry|July 3, 1998
Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinasesL Sun, N Tran, F Tang, et al.Journal of Medicinal Chemistry|July 3, 1998
Minimal-size, constrained corticotropin-releasing factor agonists with i-(i+3) Glu-Lys and Lys-Glu bridgesJ Rivier, S L Lahrichi, J Gulyas, et al.Journal of Medicinal Chemistry|July 3, 1998
Nitroaromatic amino acids as inhibitors of neuronal nitric oxide synthaseM Cowart, E A Kowaluk, J F Daanen, et al.Journal of Medicinal Chemistry|April 25, 2015
Discovery of potent indenoisoquinoline topoisomerase I poisons lacking the 3-nitro toxicophoreDaniel E Beck, Monica Abdelmalak, Wei Lv, et al.Journal of Medicinal Chemistry|April 28, 2015
First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis ActivityWai Soon Eng, Dana Hocková, Petr Špaček, et al.Journal of Medicinal Chemistry|April 22, 2015
Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of ActionIvana Mejdrová, Dominika Chalupská, Martin Kögler, et al.Pageof 3,134