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Journal of Medicinal Chemistry|August 16, 2016
1,2-Benzisoselenazol-3(2H)-one Derivatives As a New Class of Bacterial Urease InhibitorsKatarzyna Macegoniuk, Ewa Grela, Jerzy Palus, et al.Journal of Medicinal Chemistry|August 17, 2016
Thrombospondin-1 Mimetic Agonist Peptides Induce Selective Death in Tumor Cells: Design, Synthesis, and Structure-Activity Relationship StudiesThomas Denèfle, Héloise Boullet, Linda Herbi, et al.Journal of Medicinal Chemistry|October 22, 2019
Strategies for Late-Stage Optimization: Profiling Thermodynamics by Preorganization and Salt Bridge ShieldingAnna Sandner, Tobias Hüfner-Wulsdorf, Andreas Heine, et al.Journal of Medicinal Chemistry|February 6, 2018
The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular DegenerationChristopher M Adams, Karen Anderson, Gerald Artman, et al.Journal of Medicinal Chemistry|February 6, 2018
Structure-Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo ProfilesDominik Dolles, Matthias Hoffmann, Sandra Gunesch, et al.Journal of Medicinal Chemistry|February 6, 2018
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug DesignNicholas A MeanwellJournal of Medicinal Chemistry|February 7, 2018
Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor EfficacySouvik Banerjee, Kinsie E Arnst, Yuxi Wang, et al.Journal of Medicinal Chemistry|February 7, 2018
The Synthesized Plant Metabolite 3,4,5-Tri-O-Galloylquinic Acid Methyl Ester Inhibits Calcium Oxalate Crystal Growth in a Drosophila Model, Downregulates Renal Cell Surface Annexin A1 Expression, and Decreases Crystal Adhesion to CellsMohamed Abd El-Salam, Jairo Kenupp Bastos, Jing Jing Han, et al.Journal of Medicinal Chemistry|February 8, 2018
Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide AntibioticsA-Long Cui, Xin-Xin Hu, Yan Gao, et al.Journal of Medicinal Chemistry|March 17, 2018
Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin NeddylationJared T Hammill, Deepak Bhasin, Daniel C Scott, et al.Pageof 3,134