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Journal of Medicinal Chemistry|December 13, 2006
Flavonoid dimers as bivalent modulators for P-glycoprotein-based multidrug resistance: synthetic apigenin homodimers linked with defined-length poly(ethylene glycol) spacers increase drug retention and enhance chemosensitivity in resistant cancer cellsKin-Fai Chan, Yunzhe Zhao, Brendan A Burkett, et al.Journal of Medicinal Chemistry|December 13, 2006
Bridging chemical and biological space: "target fishing" using 2D and 3D molecular descriptorsJames H Nettles, Jeremy L Jenkins, Andreas Bender, et al.Journal of Medicinal Chemistry|December 13, 2006
2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitorJagabandhu Das, Ping Chen, Derek Norris, et al.Journal of Medicinal Chemistry|December 13, 2006
trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonistJuan Pablo Cueva, Gianfabio Giorgioni, Russell A Grubbs, et al.Journal of Medicinal Chemistry|December 13, 2006
Improved therapeutic efficacy of doxorubicin through conjugation with a novel peptide drug delivery technology (Vectocell)Florence Meyer-Losic, Jérôme Quinonero, Vincent Dubois, et al.Journal of Medicinal Chemistry|December 13, 2006
Common pharmacophores for uncharged human ether-a-go-go-related gene (hERG) blockersAlex M AronovJournal of Medicinal Chemistry|December 13, 2006
Antitumor activity of substituted E-3-(3,4,5-trimethoxybenzylidene)-1,3-dihydroindol-2-ones1Aldo Andreani, Silvia Burnelli, Massimiliano Granaiola, et al.Journal of Medicinal Chemistry|December 8, 2006
Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1)Hemaka A Rajapakse, Philippe G Nantermet, Harold G Selnick, et al.Journal of Medicinal Chemistry|December 8, 2006
Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibitionJohannes Trapp, Anne Jochum, Rene Meier, et al.Journal of Medicinal Chemistry|December 8, 2006
Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen receptors alpha and betaFrederik Roelens, Nina Heldring, Willem Dhooge, et al.Pageof 3,134