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Journal of Medicinal Chemistry|October 22, 2010
Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and Michael acceptor group for maximal potencyChia-Hsien Wu, Mohane Selvaraj Coumar, Chang-Ying Chu, et al.Journal of Medicinal Chemistry|December 30, 2010
Identifying chelators for metalloprotein inhibitors using a fragment-based approachJennifer A Jacobsen, Jessica L Fullagar, Melissa T Miller, et al.Journal of Medicinal Chemistry|December 30, 2010
New drug-like hydroxyphenylnaphthol steroidomimetics as potent and selective 17β-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of estrogen-dependent diseasesSandrine Marchais-Oberwinkler, Marie Wetzel, Erika Ziegler, et al.Journal of Medicinal Chemistry|December 23, 2010
Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancerFabrice Pierre, Peter C Chua, Sean E O'Brien, et al.Journal of Medicinal Chemistry|December 29, 2010
Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2John J Caldwell, Emma J Welsh, Cornelis Matijssen, et al.Journal of Medicinal Chemistry|December 7, 2010
Discovery of novel N-β-D-xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetesChun-Hsu Yao, Jen-Shin Song, Chiung-Tong Chen, et al.Journal of Medicinal Chemistry|December 7, 2010
Development of potent μ and δ opioid agonists with high lipophilicityYeon Sun Lee, Vinod Kulkarani, Scott M Cowell, et al.Journal of Medicinal Chemistry|December 7, 2010
Arylpiperazines for management of benign prostatic hyperplasia: design, synthesis, quantitative structure-activity relationships, and pharmacokinetic studiesAmit Sarswat, Rajeev Kumar, Lalit Kumar, et al.Journal of Medicinal Chemistry|December 7, 2010
Trends in kinase selectivity: insights for target class-focused library screeningShana L Posy, Mark A Hermsmeier, Wayne Vaccaro, et al.Journal of Medicinal Chemistry|December 7, 2010
Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substratesDimitri Topalis, Ugo Pradère, Vincent Roy, et al.Pageof 3,134