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RSC Medicinal Chemistry|February 19, 2026
Discovery of RP-37 analogues as potent, selective irreversible inhibitors targeting DNA polymerase theta (POLθ)Zhenwei Wang, Mengyuan Qiu, Deming Liu, et al.
RSC Medicinal Chemistry|March 13, 2026
Bisarylthiourea comprising cycloalkyl-thiophene-3-carboxylate derivatives as potential human toll-like receptor (TLR2) agonists: design, synthesis, and structure-activity relationship enabling the switch from TLR2/1 to TLR2/6 activationMunugala Chandrakanth, Yoshikazu Honda-Okubo, Arya C G, et al.
RSC Medicinal Chemistry|March 9, 2026
ZRMQ-22, a novel DYRK1A inhibitor, attenuates neuroinflammation and cognitive impairments in LPS-induced mice: a potential strategy for Alzheimer's diseaseMengyu Ren, Huanhua Chen, Zhenshu Li, et al.
RSC Medicinal Chemistry|March 9, 2026
PROTAC approaches against drug-resistant EGFRC797S/L858R/T790M mutants: biological evaluation and SAR studies (2020-2025)Ankush Kumar, Vishakha Sharma, Pallvi Kumari, et al.
RSC Medicinal Chemistry|February 23, 2024
Design, synthesis and biological evaluation of novel morpholinopyrimidine-5-carbonitrile derivatives as dual PI3K/mTOR inhibitorsGhada S Rady, Moshira A El Deeb, Marwa T M Sarg, et al.
RSC Medicinal Chemistry|February 23, 2024
Kinase inhibitor macrocycles: a perspective on limiting conformational flexibility when targeting the kinome with small moleculesBaku Acharya, Debasmita Saha, Daniel Armstrong, et al.
RSC Medicinal Chemistry|February 23, 2024
Discovery of dual-action phenolic 4-arylidene-isoquinolinones with antioxidant and α-glucosidase inhibition activitiesEduardo Hernández-Vázquez, Siseth Martínez-Caballero, Diana Aldana-Torres, et al.
RSC Medicinal Chemistry|February 23, 2024
Design, synthesis and evaluation of 2-phenylpyrimidine derivatives as novel antifungal agents targeting CYP51Zixuan Gao, Jiachen Zhang, Kejian Li, et al.
RSC Medicinal Chemistry|February 23, 2024
Highly potent and selective phosphatidylinositol 4-kinase IIIβ inhibitors as broad-spectrum anti-rhinoviral agentsAvinash G Vishakantegowda, Dasom Hwang, Prashant Chakrasali, et al.
RSC Medicinal Chemistry|March 22, 2024
Correction: Minimising the payload solvent exposed hydrophobic surface area optimises the antibody-drug conjugate propertiesAdrian D Hobson, Haizhong Zhu, Wei Qiu, et al.
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