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Science Signaling|July 22, 2025
Reporter-based screening identifies RAS-RAF mutations as drivers of resistance to active-state RAS inhibitors in colorectal cancerOleksandra Aust, Moritz R T Thiel, Eric Blanc, et al.Science Signaling|July 1, 2025
A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer's diseaseMaria Celeste Gauron, Dmitry Prokopenko, Sanghun Lee, et al.Science Signaling|June 24, 2025
The lncRNA Gas5 is an activity-responsive scaffold that mediates cAMP-dependent synaptic plasticityKaushik Chanda, Eddie Grinman, Kaylyn Clark, et al.Science Signaling|June 17, 2025
Intracellular and nuclear CXCR4 signaling promotes terminal erythroblast differentiation and enucleationJulia Christine Gutjahr, Elin Hub, Caroline Amy Anderson, et al.Science Signaling|June 17, 2025
Amphiregulin contributes to neuropathic pain by enhancing glycolysis that stimulates histone lactylation in sensory neuronsYu-Tao Deng, Longfei Ma, Yixiao Mei, et al.Science Signaling|June 10, 2025
An in vivo screen identifies diverse domains that can act as force-dependent proteolytic switches for Notch activationFrederick C Baker, Jacob Harman, Trevor Jordan, et al.Science Signaling|June 3, 2025
The E3 ligase TRIM21 promotes progression of pancreatic ductal adenocarcinoma by down-regulating TAp63α and derepressing IL20RBZejiao Li, Fengwei Gao, Xuesha Liu, et al.Pageof 321