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Science Signaling|July 1, 2025
Restoration of striatal neuroprotective pathways by kinase inhibitor treatment of Parkinson's disease-linked LRRK2-mutant miceEbsy Jaimon, Yu-En Lin, Francesca Tonelli, et al.
Science Signaling|June 24, 2025
Loss of STIM2, but not of STIM1, drives colorectal cancer metastasis through metabolic reprogramming and the ATF4 ER stress pathwayTrayambak Pathak, J Cory Benson, Martin T Johnson, et al.
Science Signaling|December 23, 2025
Cancer-associated fibroblasts confer ALK inhibitor resistance in EML4-ALK-driven lung cancer by concurrent integrin and MET signalingQianqian Hu, Lily L Remsing Rix, Bina Desai, et al.
Science Signaling|December 23, 2025
The mechanosensitive channel TRPV4 inhibits pulmonary inflammation by limiting NF-κB signaling in alveolar macrophagesAdam M Boulton, Megan E Grund, Yuxin Wang, et al.
Science Signaling|December 16, 2025
The accessory protein MRAP2 directly interacts with melanocortin-3 receptor to enhance signalingAqfan Jamaluddin, Rachael A Wyatt, Joon Lee, et al.
Science Signaling|April 15, 2025
A drug that induces the microRNA miR-124 enables differentiation of retinoic acid-resistant neuroblastoma cellsLien D Nguyen, Satyaki Sengupta, Kevin I Cho, et al.
Science Signaling|April 8, 2025
Sleep loss is a metabolic disorderSierra P Feeney, Jordan M McCarthy, Cecilia R Petruconis, et al.
Science Signaling|May 13, 2025
E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand sheddingRonja M Houtekamer, Mirjam C van der Net, Marjolein J Vliem, et al.
Science Signaling|May 20, 2025
Loss-of-function Gαs rare disease variants exert mutation-specific effects on GPCR signalingTheo Redfern-Nichols, Shannon L O'Brien, Xianglin Huang, et al.
Science Signaling|May 6, 2025
An atlas of bacterial serine-threonine kinases reveals functional diversity and key distinctions from eukaryotic kinasesBrady O'Boyle, Wayland Yeung, Jason D Lu, et al.
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