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Science Signaling|March 10, 2026
AI might be the next stage of our natural evolution: A cancer neuroscience perspectiveIhsan Ekin Demir, Carmen Mota Reyes, Maximilian Berlet, et al.Science Signaling|March 17, 2026
Redox regulation of the transcription factor HAT1 limits basal defenses and promotes responses to infection in Arabidopsis thalianaYuqing Zhao, Fan Wei, Jiahong Lao, et al.Science Signaling|March 31, 2026
The protein RAB5IF promotes BDNF signaling by stimulating the SUMOylation of Gαi1/3 to reduce depressive-like behaviors in miceXin Shi, Han-Qi Liu, Shi-Zhong Cai, et al.Science Signaling|April 14, 2026
High glucose impairs cognitive function through Creb3 O-GlcNAcylation and increased lactate productionJingxi Xu, Xing Yang, Jingxue Cao, et al.Science Signaling|April 7, 2026
Wnt-dependent Frizzled clustering is required for Dishevelled phosphorylation but insufficient for β-catenin stabilizationSarah Moldaver, Pierre E Thibeault, Mélanie Robitaille, et al.Science Signaling|April 7, 2026
Emerging paradigms in the study of brain metastasesShawn C Chafe, Daniel Mobilio, Kui Zhai, et al.Science Signaling|April 21, 2026
Activation of the NLRP3 inflammasome in osteoclasts is suppressed by a Tmem178-dependent mechanism that restricts Ca2+ influxKhushpreet Kaur, Yael Alippe, Chun Wang, et al.Science Signaling|April 21, 2026
Keeping inflammasomes in check during bone resorptionCaroline Schmidt, Ulf WagnerPageof 321