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Science Signaling|November 18, 2025
CoDIAC: A comprehensive approach for interaction analysis provides insights into SH2 domain function and regulationAlekhya Kandoor, Gabrielle Martinez, Julianna M Hitchcock, et al.Science Signaling|January 6, 2026
The ubiquitin E3 ligase HRD1 restricts hepatic lipid metabolism by suppressing PPARα-driven m6A RNA modificationHyunbae Kim, Pattaraporn Thepsuwan, Juncheng Wei, et al.Science Signaling|July 8, 2025
Evolution of growth factor signaling to the TSC complex to regulate mTORC1Kun Wang, Sophie E Lockwood, Brendan D ManningScience Signaling|July 8, 2025
The MDM2-p53 axis regulates norrin/frizzled4 signaling and blood-CNS barrier functionJacklyn Levey, Md Abedin, Chi Zhang, et al.Science Signaling|July 15, 2025
Astrocytic RIPK3 exerts protective anti-inflammatory activity in mice with viral encephalitis by transcriptional induction of serpinsMarissa Lindman, Irving Estevez, Eduard Marmut, et al.Science Signaling|September 23, 2025
Adenosine 2A receptor-dependent activation of AMPK represses TH17 cell pathogenicity through epigenetic and metabolic reprogrammingGina Papadopoulou, Dimitrios Valakos, Ioanna Polydouri, et al.Science Signaling|May 20, 2025
Technical recommendations for analyzing oxylipins by liquid chromatography-mass spectrometryNils Helge Schebb, Nadja Kampschulte, Gerhard Hagn, et al.Science Signaling|May 13, 2025
ADAR2-mediated Q/R editing of GluA2 in homeostatic synaptic plasticityLucy Peterson, Richard Coca, Shreya Parikh, et al.Science Signaling|May 27, 2025
SMAD2 S-palmitoylation promotes its linker region phosphorylation and TH17 cell differentiation in a mouse model of multiple sclerosisMingming Zhang, Tao Yu, Yinong Liu, et al.Science Signaling|July 22, 2025
Deletion of PTP1B in cardiomyocytes alters cardiac metabolic signaling to protect against cardiomyopathy induced by a high-fat dietYan Sun, Abhishek Kumar Mishra, Vasanth Chanrasekhar, et al.Pageof 320