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Science Translational Medicine|May 22, 2024
Gain-of-function mutations of TRPV4 acting in endothelial cells drive blood-CNS barrier breakdown and motor neuron degeneration in miceJeremy M Sullivan, Anna M Bagnell, Jonathan Alevy, et al.
Science Translational Medicine|May 22, 2024
Preclinical efficacy and pharmacokinetics of an RNA-encoded T cell-engaging bispecific antibody targeting human claudin 6Christiane R Stadler, Ursula Ellinghaus, Leyla Fischer, et al.
Science Translational Medicine|May 29, 2024
Payload-delivering engineered γδ T cells display enhanced cytotoxicity, persistence, and efficacy in preclinical models of osteosarcomaDaniel Fowler, Marta Barisa, Alba Southern, et al.
Science Translational Medicine|May 15, 2024
Comparative analysis of SARS-CoV-2 neutralization titers reveals consistency between human and animal model serum and across assaysBarbara Mühlemann, Samuel H Wilks, Lauren Baracco, et al.
Science Translational Medicine|May 15, 2024
SRC inhibition enables formation of a growth suppressive MAGI1-PP2A complex in isocitrate dehydrogenase-mutant cholangiocarcinomaIris S Luk, Caroline M Bridgwater, Angela Yu, et al.
Science Translational Medicine|May 15, 2024
Tumor-associated NK cells drive MDSC-mediated tumor immune tolerance through the IL-6/STAT3 axisShi Yong Neo, Le Tong, Joni Chong, et al.
Science Translational Medicine|June 5, 2024
Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retinal degenerationJian Liu, David A Copland, Alison J Clare, et al.
Science Translational Medicine|June 5, 2024
Muscle-bone cross-talk through the FNIP1-TFEB-IGF2 axis is associated with bone metabolism in human and mouseYan Mao, Zhen Jin, Jing Yang, et al.
Science Translational Medicine|June 5, 2024
High-throughput mass spectrometry maps the sepsis plasma proteome and differences in patient responseYuxin Mi, Katie L Burnham, Philip D Charles, et al.
Science Translational Medicine|June 5, 2024
Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degenerationMarvin Reich, Matthew J Simon, Beate Polke, et al.
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