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Science Translational Medicine|September 24, 2025
USP5 inhibition enables potential therapy for t(8;21) AML through ubiquitin-mediated AML1-ETO degradation in patient-derived xenograftsLan Ma, Kun Zhang, Zixuan Zhang, et al.
Science Translational Medicine|October 15, 2025
An intramuscular prime and mucosal boost vaccine regimen protects against lethal clade 2.3.4.4b H5N1 challenge in cynomolgus macaquesNinaad Lasrado, Liping Wang, Jinyan Liu, et al.
Science Translational Medicine|October 15, 2025
Deletion of the X-chromosomal gene Kdm6a in microglia of female mice ameliorates neuroinflammation and restores translatome profilesYuichiro Itoh, Noriko Itoh, Sophia Wendin, et al.
Science Translational Medicine|October 15, 2025
Low-dose glucocorticoids attenuate crescentic glomerulonephritis by inhibiting the local differentiation of proinflammatory neutrophilsJunping Yin, Melanie Eichler, Darius P Schaub, et al.
Science Translational Medicine|October 15, 2025
Biselective remodeling of the melanoma tumor microenvironment prevents metastasis and enhances immune activation in mouse modelsNikolaos A Afratis, Shivang Parikh, Idan Adir, et al.
Science Translational Medicine|August 6, 2025
Regulatory KIR+CD8+ T cells are elevated during human pregnancyJing Li, Xuerui Wang, Andreas I Lackner, et al.
Science Translational Medicine|July 30, 2025
Systematic analysis of cellular cross-talk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer's diseaseRicardo D'Oliveira Albanus, Gina M Finan, Logan Brase, et al.
Science Translational Medicine|July 30, 2025
AGPAT4 targeted covalent inhibitor potentiates targeted therapy to overcome cancer cell plasticity in hepatocellular carcinoma mouse modelsKai-Yu Ng, Tin-Yan Koo, Ianto Bosheng Huang, et al.
Science Translational Medicine|July 30, 2025
NFIA regulates articular chondrocyte fatty acid metabolism and joint homeostasisCuicui Wang, Liang Fang, Meng Shi, et al.
Science Translational Medicine|August 6, 2025
Nasal and systemic immune responses correlate with viral shedding after influenza challenge in people with complex preexisting immunityKathie-Anne Walters, Charles A Blatti, Ruoqing Zhu, et al.
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