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Science Translational Medicine|March 5, 2025
Targeting GOLPH3L improves glioblastoma radiotherapy by regulating STING-NLRP3-mediated tumor immune microenvironment reprogrammingShuo Sun, Shiyu Qian, Ran Wang, et al.Science Translational Medicine|February 26, 2025
Reduced cerebellar rhythm by climbing fiber denervation is linked to motor rhythm deficits in mice and ataxia severity in patientsChih-Chun Lin, Ke-Chu Fang, Ilaria Balbo, et al.Science Translational Medicine|January 29, 2025
Correcting a pathogenic mitochondrial DNA mutation by base editing in miceJose D Barrera-Paez, Sandra R Bacman, Till Balla, et al.Science Translational Medicine|January 29, 2025
Early-onset sleep alterations found in patients with amyotrophic lateral sclerosis are ameliorated by orexin antagonist in mouse modelsSimon J Guillot, Christina Lang, Marie Simonot, et al.Science Translational Medicine|January 15, 2025
Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathyWesley Brandao, Nimansha Jain, Zhuoran Yin, et al.Science Translational Medicine|January 15, 2025
Gene therapy ameliorates bowel dysmotility and enteric neuron degeneration and extends survival in lysosomal storage disorder mouse modelsEwa A Ziółkowska, Matthew J Jansen, Letitia L Williams, et al.Science Translational Medicine|January 8, 2025
The protein kinase C modulator bryostatin-1 therapeutically targets microglia to attenuate neuroinflammation and promote remyelinationPayam Gharibani, Efrat Abramson, Shruthi Shanmukha, et al.Science Translational Medicine|January 8, 2025
An engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutationsOlivia M Swanson, Qianyi E Zhang, Elizabeth Van Itallie, et al.Science Translational Medicine|January 22, 2025
Cardiac allograft tolerance can be achieved in nonhuman primates by donor bone marrow and kidney cotransplantationMakoto Tonsho, Jane M O, Kaitlan Ahrens, et al.Science Translational Medicine|January 15, 2025
Epithelial OPA1 links mitochondrial fusion to inflammatory bowel diseaseLi-Li Bao, Yu-Qiang Yu, Miguel González-Acera, et al.Pageof 489