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Science Translational Medicine|September 21, 2022
Giredestrant reverses progesterone hypersensitivity driven by estrogen receptor mutations in breast cancerJackson Liang, Ellen Rei Ingalla, Xiaosai Yao, et al.Science Translational Medicine|November 3, 2022
S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and ameliorates COVID-19 severity in hamstersMichihito Sasaki, Koshiro Tabata, Mai Kishimoto, et al.Science Translational Medicine|December 6, 2023
Zinc prevents vaginal candidiasis by inhibiting expression of an inflammatory fungal proteinElena Roselletti, Eva Pericolini, Alexandre Nore, et al.Science Translational Medicine|December 6, 2023
USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in miceFabin Dang, Lei Bai, Jiazhen Dong, et al.Science Translational Medicine|December 6, 2023
Ex vivo tissue perturbations coupled to single-cell RNA-seq reveal multilineage cell circuit dynamics in human lung fibrogenesisNiklas J Lang, Janine Gote-Schniering, Diana Porras-Gonzalez, et al.Science Translational Medicine|November 22, 2023
Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiencyJudith Y Altarejos, Jeffrey Pangilinan, Simona Podgrabinska, et al.Science Translational Medicine|November 29, 2023
Enhanced mTORC1 signaling and protein synthesis in pathologic α-synuclein cellular and animal models of Parkinson's diseaseMohammed Repon Khan, Xiling Yin, Sung-Ung Kang, et al.Science Translational Medicine|November 15, 2023
Targeting DNA methylation and B7-H3 in RB1-deficient and neuroendocrine prostate cancerYasutaka Yamada, Varadha Balaji Venkadakrishnan, Kei Mizuno, et al.Science Translational Medicine|January 17, 2024
Antibodies targeting the fusion peptide on the HIV envelope provide protection to rhesus macaques against mucosal SHIV challengeAmarendra Pegu, Sarah E Lovelace, Megan E DeMouth, et al.Science Translational Medicine|January 17, 2024
Fusion peptide-directed antibodies: Humoral armor against HIV-1 infectionP J KlassePageof 482