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Signal Transduction and Targeted Therapy|January 15, 2026
The aryl hydrocarbon receptor: structure, signaling, physiology and pathologyXavier Coumoul, Robert Barouki, Charlotte Esser, et al.
Signal Transduction and Targeted Therapy|December 30, 2025
mTOR signaling networks: mechanistic insights and translational frontiers in disease therapeuticsHanxiao Zhang, Xia Xiao, Zhenrui Pan, et al.
Signal Transduction and Targeted Therapy|December 23, 2025
Lipocalin-2 drives brain metastatic progression through reciprocal tumor-microenvironment interactions in lung cancerYixiang Zhu, Jian Zhang, Danming He, et al.
Signal Transduction and Targeted Therapy|November 3, 2025
Olverembatinib, a multikinase inhibitor that modulates lipid metabolism, in advanced succinate dehydrogenase-deficient gastrointestinal stromal tumors: a phase 1b study and translational researchHai-Bo Qiu, Zhiyan Liang, Jing Yang, et al.
Signal Transduction and Targeted Therapy|November 4, 2025
A novel long-acting C5a-blocking cyclic peptide prevents sepsis-induced organ dysfunction via effective blockade of the inflammatory cascadeZimiao Luo, Pengfei Luo, Haoyu Gu, et al.
Signal Transduction and Targeted Therapy|October 23, 2025
Navigating the landscape of protein folding and proteostasis: from molecular chaperones to therapeutic innovationsOmer Faruk Kuzu, Lars Jørgen Tvenge Granerud, Fahri Saatcioglu
Signal Transduction and Targeted Therapy|October 13, 2025
Multi-omics reveal critical roles of phosphatidylcholine and sphingomyelin in antipsychotic efficacy for schizophreniaJunyuan Sun, Zhe Lu, Zhewei Kang, et al.
Signal Transduction and Targeted Therapy|October 14, 2025
In vivo self-assembled nano-PROTAC for the dual degradation of AR and HSP90 to overcome castration-resistant prostate cancer resistanceFei-Ya Yang, Ni-Yuan Zhang, Yang Yang, et al.
Signal Transduction and Targeted Therapy|October 12, 2025
First-line treatment with chemotherapy, surufatinib (an angio-immuno kinase inhibitor), and camrelizumab (an anti-PD-1 antibody) for locally advanced or metastatic pancreatic ductal adenocarcinoma: a phase Ib/II randomized studyRu Jia, Hai-Yan Si, Meng-Jiao Fan, et al.
Signal Transduction and Targeted Therapy|October 14, 2025
Regulatory T cells in homeostasis and disease: molecular mechanisms and therapeutic potentialLingling Wang, Ying Liang, Chunxia Zhao, et al.
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