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Signal Transduction and Targeted Therapy|June 24, 2025
Multicenter phase 1/2 study of onatasertib, a dual TORC1/2 inhibitor, combined with the PD-1 antibody toripalimab in advanced solid tumorsPei Shu, Xiaoyu Li, Qi Zhou, et al.
Signal Transduction and Targeted Therapy|December 18, 2025
Novel CDK2/4/6 inhibitor culmerciclib (TQB3616) plus fulvestrant in previously treated, HR-positive, HER2-negative advanced breast cancer: a randomized, double-blind, phase 3 trialYongmei Yin, Qingyuan Zhang, Tao Sun, et al.
Signal Transduction and Targeted Therapy|December 15, 2025
Nucleosome assembly protein-like 1 degradation-dependent novel cardioprotection mechanism of Wnt2 against ischemia‒reperfusion injuryYing Wang, Liming Chen, Jinyi Lin, et al.
Signal Transduction and Targeted Therapy|December 14, 2025
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responsesJing Sun, Wenwen Zheng, Zheng-Guo Zhang, et al.
Signal Transduction and Targeted Therapy|December 11, 2025
Efficacy and safety of L-oxiracetam on cognitive function in patients with traumatic brain injury: a multicentre, randomised, double-blind, phase 3 clinical trialTao Liu, Jiao Wang, Zhihao Zhao, et al.
Signal Transduction and Targeted Therapy|December 4, 2025
Bruceine A protects nuclear receptor 4A1 from ubiquitin-degradation to alleviate mesangial proliferative glomerulonephritisHuating Hu, Runze Li, Kancheng He, et al.
Signal Transduction and Targeted Therapy|June 21, 2025
TSC22 domain family member 3 links natural killer cells to CD8+ T cell-mediated drug hypersensitivityLele Sun, Pengcheng Huai, Zhenzhen Wang, et al.
Signal Transduction and Targeted Therapy|February 13, 2025
Full-length transcriptome atlas of gallbladder cancer reveals trastuzumab resistance conferred by ERBB2 alternative splicingZiyi Wang, Li Gao, Ziheng Jia, et al.
Signal Transduction and Targeted Therapy|December 27, 2024
Itaconate facilitates viral infection via alkylating GDI2 and retaining Rab GTPase on the membraneShulei Yin, Yijie Tao, Tianliang Li, et al.
Signal Transduction and Targeted Therapy|February 9, 2025
Spatiotemporal transcriptomics elucidates the pathogenesis of fulminant viral myocarditisHuihui Li, Xueting Chen, James Jiqi Wang, et al.
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