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Signal Transduction and Targeted Therapy|December 17, 2025
Hypoglycemia induces brain metabolic reprogramming and neurodegeneration via serum response factor and myocardin-related transcription factor-AMinjeong Jang, Hyung Jin Choi, Hae-June Lee, et al.
Signal Transduction and Targeted Therapy|December 17, 2025
Disruption of heme homeostasis by nuclear receptor Nur77 induces pyroptosis through granzyme B-dependent GSDMC cleavageLiu-Zheng Wu, Ya-Ying Huang, Hai-Jing Hu, et al.
Signal Transduction and Targeted Therapy|December 23, 2025
Targeting SKAP2 restores sperm motility and morphology through modulating mitochondrial organization and cytoskeletal remodelingShiming Gan, Lin Yin, Jiaming Zhou, et al.
Signal Transduction and Targeted Therapy|December 29, 2025
A novel antituberculosis agent exhibits potent clinical efficacy and good safety profile: an open-label, randomized-controlled, multicenter, phase 2a trialNaihui Chu, Wenjuan Nie, Juan Du, et al.
Signal Transduction and Targeted Therapy|December 28, 2025
Dysadherin/YAP axis fuels stem plasticity and immune escape in liver cancerTae-Young Jang, So-El Jeon, Hyeon-Ji Yun, et al.
Signal Transduction and Targeted Therapy|November 27, 2025
Preoperative pembrolizumab (anti-PD-1 antibody) combined with chemoradiotherapy for esophageal squamous cell carcinoma: a phase 1/2 trial (PALACE-2)Chengqiang Li, Yichao Han, Shengguang Zhao, et al.
Signal Transduction and Targeted Therapy|November 20, 2025
Dynamic transcriptional immune landscape in response to NK-cell therapy combined with gemcitabine plus S-1 in advanced pancreatic cancer: a phase 1b/2 trialQin Tan, Yifei Li, Caixia Liu, et al.
Signal Transduction and Targeted Therapy|May 7, 2024
A pathological joint-liver axis mediated by matrikine-activated CD4+ T cellsJunzhi Yi, Hui Zhang, Fangyuan Bao, et al.
Signal Transduction and Targeted Therapy|May 3, 2024
Combination therapy with oncolytic virus and T cells or mRNA vaccine amplifies antitumor effectsRao Fu, Ruoyao Qi, Hualong Xiong, et al.
Signal Transduction and Targeted Therapy|May 5, 2024
Haploidentical hematopoietic cell transplantation with or without an unrelated cord blood unit for adult acute myeloid leukemia: a multicenter, randomized, open-label, phase 3 trialBiqi Zhou, Jia Chen, Tianhui Liu, et al.
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