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Signal Transduction and Targeted Therapy|November 5, 2025
CDK7-targeted therapy effectively disrupts cell cycle progression and oncogenic signaling in head and neck cancerMaría Otero-Rosales, Miguel Álvarez-González, Irene Pazos, et al.
Signal Transduction and Targeted Therapy|July 8, 2025
A novel peptide 66CTG stabilizes Myc proto-oncogene protein to promote triple-negative breast cancer growthHuichun Liang, Fubing Li, Huan Fang, et al.
Signal Transduction and Targeted Therapy|July 9, 2025
Irinotecan alleviates chemoresistance to anthracyclines through the inhibition of AARS1-mediated BLM lactylation and homologous recombination repairXinyuan Li, Chunlin Zhang, Yuhua Mei, et al.
Signal Transduction and Targeted Therapy|July 8, 2025
Glioblastoma at the crossroads: current understanding and future therapeutic horizonsShilpi Singh, Devanjan Dey, Debashis Barik, et al.
Signal Transduction and Targeted Therapy|July 16, 2025
Comprehensive genomic and transcriptomic analyses reveal prognostic stratification for esophageal squamous cell carcinomaJian Gao, Qiming Wang, Fangqiu Fu, et al.
Signal Transduction and Targeted Therapy|June 25, 2025
Preclinical and first-in-human of purinostat mesylate, a novel selective HDAC I/IIb inhibitor, in relapsed/refractory multiple myeloma and lymphomaLinyu Yang, Qiang Qiu, Jie Wang, et al.
Signal Transduction and Targeted Therapy|June 23, 2025
Multi-omics dissection of MAPK-driven senescence unveils therapeutic vulnerabilities in KIAA1549::BRAF-fusion pediatric low-grade glioma modelsRomain Sigaud, Anja Stefanski, Florian Selt, et al.
Signal Transduction and Targeted Therapy|September 29, 2025
Development of a leucine-rich repeat-containing protein 15-targeted radio-immunotheranostic approach to deplete pro-tumorigenic mechanisms and immunotherapy resistanceClaire M Storey, Mohamed Altai, Katharina Lückerath, et al.
Signal Transduction and Targeted Therapy|October 13, 2025
Mesenchymal stromal cells induce neutrophil aggregation and extracellular vesicle storms for systemic lupus erythematosusQianmin Ou, Luhan Niu, Dandan Wang, et al.
Signal Transduction and Targeted Therapy|September 25, 2025
A two-strata energy flux system driven by a stress hormone prioritizes cardiac energeticsZhiheng Rao, Zhichao Chen, Yuxuan Bao, et al.
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