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Signal Transduction and Targeted Therapy|August 1, 2025
Targeting AKR1B1 inhibits metabolic reprogramming to reverse systemic therapy resistance in hepatocellular carcinomaQi Wang, Juan Liu, Ming Yang, et al.
Signal Transduction and Targeted Therapy|June 27, 2025
Reshaping the tumor microenvironment of cold soft-tissue sarcomas with anti-angiogenics: a phase 2 trial of regorafenib combined with avelumabMaud Toulmonde, Jean-Philippe Guégan, Mariella Spalato-Ceruso, et al.
Signal Transduction and Targeted Therapy|June 16, 2025
Garsorasib, a KRAS G12C inhibitor, with or without cetuximab, an EGFR antibody, in colorectal cancer cohorts of a phase II trial in advanced solid tumors with KRAS G12C mutationDan-Yun Ruan, Hao-Xiang Wu, Ye Xu, et al.
Signal Transduction and Targeted Therapy|June 11, 2025
Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advancesXieyang Xu, Yan Pang, Xianqun Fan
Signal Transduction and Targeted Therapy|March 14, 2025
PD-1 antibody camrelizumab plus apatinib and SOX as first-line treatment in patients with AFP-producing gastric or gastro-esophageal junction adenocarcinoma (CAP 06): a multi-center, single-arm, phase 2 trialYakun Wang, Jialin Lu, Xiaoyi Chong, et al.
Signal Transduction and Targeted Therapy|April 24, 2025
Diabetic neuropathy: cutting-edge research and future directionsYang Yang, Bing Zhao, Yuanzhe Wang, et al.
Signal Transduction and Targeted Therapy|April 25, 2025
A20 attenuates oxidized self-DNA-mediated inflammation in acute kidney injuryHanwen Li, Yongyao Wu, Lisha Xiang, et al.
Signal Transduction and Targeted Therapy|April 20, 2025
Subnanomolar MAS-related G protein-coupled receptor-X2/B2 antagonists with efficacy in human mast cells and disease modelsGhazl Al Hamwi, Mohamad Wessam Alnouri, Sven Verdonck, et al.
Signal Transduction and Targeted Therapy|April 20, 2025
Conversion of Ku80 K568 crotonylation to SUMOylation facilitates DNA non-homologous end joining and cancer radioresistanceHongling Zhao, Shanshan Gao, Yang Han, et al.
Signal Transduction and Targeted Therapy|May 1, 2025
Single-cell transcriptomic analysis reveals gut microbiota-immunotherapy synergy through modulating tumor microenvironmentMinyuan Cao, Yun Deng, Qing Hao, et al.
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