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Signal Transduction and Targeted Therapy|June 1, 2026
Sintilimab plus concurrent chemoradiotherapy for treatment of locally advanced small cell lung cancer (SINCE-01): a phase II clinical trialQian Zhao, Yintao Li, Hongjiao Zhang, et al.
Signal Transduction and Targeted Therapy|May 27, 2026
PRELP negatively regulates IL-17A-mediated proliferation and the inflammatory response in psoriasisCong-Cong He, Ming-Xing Lei, Jing-Wei Jiang, et al.
Signal Transduction and Targeted Therapy|May 27, 2026
Combating small extracellular vesicle-mediated immunological barriers in the tumor microenvironment via strategically activatable PEGylated peptidesChan Ho Kim, Hyewon Ko, Jae Ah Lee, et al.
Signal Transduction and Targeted Therapy|May 19, 2026
Targeting ZMIZ1 induces differentiation in acute myeloid leukemia via chromatin remodelingHuimin Li, Yabin Liu, Jiachen Cui, et al.
Signal Transduction and Targeted Therapy|May 1, 2026
Single-cell imaging analysis, therapeutic modeling and a Phase Ib trial validate BCL-2 as a target across heterogeneous castration-resistant prostate cancerAnmbreen Jamroze, Xiaozhuo Liu, Surui Hou, et al.
Signal Transduction and Targeted Therapy|May 18, 2026
Myeloid Mas drives pyruvate kinase M2-mediated Spi1 lactylation to fuel inflammatory senescence in MASLDLuying Zhao, Shujing Xu, Shikai Qiao, et al.
Signal Transduction and Targeted Therapy|May 17, 2026
VCPIP1 drives diabetic cardiomyopathy by deubiquitinating AMPKγ1 and preventing AMPKα-γ subunit assembly in cardiomyocytesXue Han, Zhuqi Huang, Guoxuan Liu, et al.
Signal Transduction and Targeted Therapy|May 16, 2026
Disrupting SOX2 self-association and condensate formation to overcome chemotherapeutic drug resistance in lung squamous cell carcinomaJuehan Wang, Yulin Wen, Sainan Huang, et al.
Signal Transduction and Targeted Therapy|May 4, 2026
Pancreatic ductal adenocarcinoma: integrating molecular insights for targeted interventionsGanji Purnachandra Nagaraju, Haasita Nellipudi, Chaithanya Ganji, et al.
Signal Transduction and Targeted Therapy|May 3, 2026
Total neoadjuvant chemotherapy combined with PD‑1 blockade and IL‑2 in MSS/pMMR locally advanced rectal cancer: short-term results of a prospective, single-arm phase II studyJunwei Tang, Lu Wang, Sheng Yang, et al.
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