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Signal Transduction and Targeted Therapy|August 17, 2026
A multicohort, biomarker-driven phase 2 trial of personalized total neoadjuvant therapy with targeted agents for high-risk rectal cancer (The TRAINER study)Tao Ma, Jingyi Liu, Sen Zhang, et al.
Signal Transduction and Targeted Therapy|August 24, 2026
Cancer-associated adipocytes: metabolic reprogramming, crosstalk and therapeutic implications in tumor progressionJinmin Shi, Shaimaa Abdel-Ghany, Mariam Abdel-Fattah, et al.
Signal Transduction and Targeted Therapy|August 25, 2026
All-trans retinoic acid suppresses CD8+ T-cell terminal exhaustion and potentiates anti-PD-1 therapy in glioblastomaIn Kang, Yumin Kim, Byeong Hoon Kang, et al.
Signal Transduction and Targeted Therapy|August 20, 2026
Glycolytic enolase 1-induced H4K12 lactylation activates quiescent breast cancer stem-like cells in triple-negative breast cancerShuai Liu, Yunfeng Ma, Yujie Zeng, et al.
Signal Transduction and Targeted Therapy|August 19, 2026
The sleep-wake cycle: molecular mechanisms, disorders, and therapeutic targets in the context of energy metabolismJia-Kang Li, Rui-Yu Wang, Xiao-Yan Meng, et al.
Signal Transduction and Targeted Therapy|June 13, 2022
RING finger 138 deregulation distorts NF-кB signaling and facilities colitis switch to aggressive malignancyYalan Lu, Rong Huang, Jianming Ying, et al.
Signal Transduction and Targeted Therapy|August 27, 2025
Transforming acidic coiled-coil-containing protein 3-mediated lipid metabolism reprogramming impairs CD8+ T-cell cytotoxicity in hepatocellular carcinomaYing Li, Zule Chen, Dongdong Wang, et al.
Signal Transduction and Targeted Therapy|May 11, 2023
Angiogenic signaling pathways and anti-angiogenic therapy for cancerZhen-Ling Liu, Huan-Huan Chen, Li-Li Zheng, et al.
Signal Transduction and Targeted Therapy|May 21, 2023
Macrophages in immunoregulation and therapeuticsShanze Chen, Abdullah F U H Saeed, Quan Liu, et al.
Signal Transduction and Targeted Therapy|August 28, 2025
The deacetylases HDAC1/HDAC2 control JAK2V617F-STAT signaling through the ubiquitin ligase SIAH2Al-Hassan M Mustafa, Giuseppe Petrosino, Marten A Fischer, et al.
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