Keith F McDaniel

4PUBLICATIONS
7CO-AUTHORS
Biomolecular modelling and designOrganometallic chemistryMedical molecular engineering of nucleic acids and proteinsBiologically active molecules
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Publications (4)

|Mar 04, 2021
Novel Physics-Based Ensemble Modeling Approach That Utilizes 3D Molecular Conformation and Packing to Access Aqueous Thermodynamic Solubility: A Case Study of Orally Available Bromodomain and Extraterminal Domain Inhibitor Lead Optimization Series.

Richard S Hong, Alessandra Mattei, Ahmad Y Sheikh

|Apr 24, 2020
Discovery of N-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain.

George S Sheppard, Le Wang, Steven D Fidanze

|Jun 01, 2018
Identification of Highly Potent Human Immunodeficiency Virus Type-1 Protease Inhibitors against Lopinavir and Darunavir Resistant Viruses from Allophenylnorstatine-Based Peptidomimetics with P2 Tetrahydrofuranylglycine.

Koushi Hidaka, Tooru Kimura, Rajesh Sankaranarayanan

|Sep 27, 2017
Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.

Keith F McDaniel, Le Wang, Todd Soltwedel

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Frequent Collaborators

2 joint publications

John K Pratt

1 joint publications

Koushi Hidaka

1 joint publications

Yoshio Hayashi

1 joint publications

Yoshiaki Kiso