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David Harrison

5PUBLICATIONS

5CO-AUTHORS

Neurology and neuromuscular diseasesCheminformatics and quantitative structure-activity relationshipsInnate immunity

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Publications (5)

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|Sep 08, 2025

Profile of NT-0527, a brain penetrant NLRP3 Inflammasome inhibitor suitable as an <i>in vivo</i> tool compound for neuroinflammatory disorders.

David Harrison, Andy Billinton, Mark G Bock

|Dec 02, 2024

Brain Penetrant NLRP3 Inhibitors: The Discovery of a Panacea?

David Harrison

|May 16, 2024

Pharmacological Analysis of NLRP3 Inflammasome Inhibitor Sodium [(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl][(1-methyl-1<i>H</i>-pyrazol-4-yl)({[(2<i>S</i>)-oxolan-2-yl]methyl})sulfamoyl]azanide in Cellular and Mouse Models of Inflammation Provides a Translational Framework.

John R Doedens, Pamela Smolak, MyTrang Nguyen

|Oct 24, 2023

Discovery of Clinical Candidate NT-0796, a Brain-Penetrant and Highly Potent NLRP3 Inflammasome Inhibitor for Neuroinflammatory Disorders.

David Harrison, Andy Billinton, Mark G Bock

|Aug 18, 2022

Discovery and Optimization of Triazolopyrimidinone Derivatives as Selective NLRP3 Inflammasome Inhibitors.

David Harrison, Mark G Bock, John R Doedens

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Frequent Collaborators

2 joint publications

M Katharine Holloway

1 joint publications

Roderick A Porter

1 joint publications

Valérie Reader

1 joint publications

Christopher A Gabel

1 joint publications

Nicholas P Clarke

Frequent Collaborators

2 joint publications

M Katharine Holloway

1 joint publications

Roderick A Porter

1 joint publications

Valérie Reader

1 joint publications

Christopher A Gabel

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