Christian Speck

12PUBLICATIONS
29CO-AUTHORS
Epigenetics (incl. genome methylation and epigenomics)Genome structure and regulationPowder and particle technologyMedical infection agents (incl. prions)Molecular targets
Featured researcher

Get your video featured.

JoVEPublish with JoVE
Journal

Publications (12)

|Dec 09, 2025
Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactions.

Joshua Tomkins, Lucy V Edwardes, Sarah V Faull

|May 19, 2025
Compact Origins and Where to Find Them: ORC's Guide to Genome-Wide Licensing.

Christian Speck, Luitpold Maximilian Reuter

|Jan 08, 2025
Reconstitution of human DNA licensing and the structural and functional analysis of key intermediates.

Jennifer N Wells, Lucy V Edwardes, Vera Leber

|Jan 02, 2025
MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis.

Sarah V Faull, Marta Barbon, Audrey Mossler

|Aug 24, 2024
MCM2-7 loading-dependent ORC release ensures genome-wide origin licensing.

L Maximilian Reuter, Sanjay P Khadayate, Audrey Mossler

|May 25, 2022
The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer.

Almutasem Saleh, Yasunori Noguchi, Ricardo Aramayo

Pageof 2