Frank J Dekker

30PUBLICATIONS
56CO-AUTHORS
Cheminformatics and quantitative structure-activity relationshipsBiologically active moleculesHaematological tumoursMolecular targetsMedical infection agents (incl. prions)
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Publications (30)

|Jul 06, 2026
Development of Indole-3-yl-methylene-thiobarbital Derivatives as Inhibitors of HDAC8 Enzyme Activity.

|Mar 02, 2026
Discovery of Furan-2-Carboxylic Acid Derivatives as Novel D-Dopachrome Tautomerase (D-DT) and Macrophage Migration Inhibitory Factor-1 (MIF-1) Dual Inhibitors.

Zhengyang Wu, Vinnie Widjaja, Erin Skeens

|Aug 01, 2024
Exploration of Hydrazide-Based HDAC8 PROTACs for the Treatment of Hematological Malignancies and Solid Tumors.

Chunlong Zhao, Jianqiu Zhang, Hangyu Zhou

|Jun 26, 2024
Small Molecule MIF Modulation Enhances Ferroptosis by Impairing DNA Repair Mechanisms.

Deng Chen, Chunlong Zhao, Jianqiu Zhang

|Aug 28, 2023
Histone Deacetylase 3-Directed PROTACs Have Anti-inflammatory Potential by Blocking Polarization of M0-like into M1-like Macrophages.

Chunlong Zhao, Shipeng Chen, Deng Chen

|Jun 23, 2023
Allosteric Inhibitors of Macrophage Migration Inhibitory Factor (MIF) Interfere with Apoptosis-Inducing Factor (AIF) Co-Localization to Prevent Parthanatos.

Deng Chen, Angelina Osipyan, Jeaunice Adriana

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Frequent Collaborators

8 joint publications

Gerrit J Poelarends

6 joint publications

Deng Chen

6 joint publications

Zhangping Xiao

4 joint publications

Wim J Quax