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Patrick O'Brien

12PUBLICATIONS
30CO-AUTHORS
NeurogeneticsCell and nuclear divisionEpigenetics (incl. genome methylation and epigenomics)Liquid biopsiesQuality assurance, chemometrics, traceability and metrological chemistry
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Journal

Publications (12)

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|Mar 02, 2026
Huntington's disease LIG1 modifier variant increases ligase fidelity and suppresses somatic CAG repeat expansion.

Eunhye Lee, Wonju Kim, David H Beier

|Apr 16, 2025
Molecular basis for RNA discrimination by human DNA ligase 1.

Percy P Tumbale, Thomas J Jurkiw, Juno M Krahn

|Jul 17, 2023
Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1.

Lindsay Moritz, Samantha B Schon, Mashiat Rabbani

|Jan 10, 2023
Human DNA ligases I and III have stand-alone end-joining capability, but differ in ligation efficiency and specificity.

Justin R McNally, Amanda M Ames, Suzanne J Admiraal

|May 11, 2022
Genetic and chemotherapeutic influences on germline hypermutation.

Joanna Kaplanis, Benjamin Ide, Rashesh Sanghvi

|Nov 30, 2019
Two-tiered enforcement of high-fidelity DNA ligation.

Percy P Tumbale, Thomas J Jurkiw, Matthew J Schellenberg

Pageof 2

Frequent Collaborators

2 joint publications

Suzanne J Admiraal

2 joint publications

R Scott Williams

1 joint publications

Daniel E Eyler

1 joint publications

Kylie A Burnham

1 joint publications

Thomas E Wilson

1 joint publications

Justin R McNally

1 joint publications

Christopher J Schofield

1 joint publications

Thomas J Jurkiw

1 joint publications

Matthew J Schellenberg

1 joint publications

Juniper Glass-Klaiber

Frequent Collaborators

2 joint publications

Suzanne J Admiraal

2 joint publications

R Scott Williams

1 joint publications

Daniel E Eyler

1 joint publications

Kylie A Burnham

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