Shimon Sakaguchi

30PUBLICATIONS
142CO-AUTHORS
Epigenetics (incl. genome methylation and epigenomics)Tumour immunologyApplied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies)Innate immunityGenome structure and regulation
Featured researcher

Get your video featured.

JoVEPublish with JoVE
Journal

Publications (30)

|Oct 14, 2026
Autoimmunity induced by epigenome alteration affecting thymic Treg cell development.

|May 01, 2026
Foxp3 drives context-dependent epigenetic programs that define regulatory T cell molecular identity and function.

|Apr 08, 2026
PD-1 antibody-bound progenitor-exhausted CD8+ T cells in lymph nodes boost PD-1-blockade anti-tumor immunity in gastrointestinal cancer.

Yohei Nose, Yoshiaki Yasumizu, Takuro Saito

|Dec 04, 2025
Prostaglandin E2-EP2/EP4 signaling induces the tumor-infiltrating Treg phenotype for tumor growth.

Ryuma Matsuura, Siwakorn Punyawatthananukool, Ryoji Kawakami

|Oct 22, 2025
Conversion of pathogenic T cells into functionally stabilized Treg cells for antigen-specific immunosuppression in pemphigus vulgaris.

Miho Mukai, Hayato Takahashi, Yoko Kubo

|Oct 22, 2025
Generating functionally stable and antigen-specific Treg cells from effector T cells for cell therapy of inflammatory diseases.

Norihisa Mikami, Ryoji Kawakami, Atsushi Sugimoto

Pageof 5

Frequent Collaborators

9 joint publications

Ryoji Kawakami

8 joint publications

Norihisa Mikami

5 joint publications

James B Wing

3 joint publications

Yusuke Takeshima