Elizabeth Liesbeth Cm de Lange

18PUBLICATIONS
23CO-AUTHORS
PharmacogenomicsToxicology (incl. clinical toxicology)Pharmaceutical delivery technologiesCellular nervous systemProteomics and metabolomics
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Publications (18)

|Sep 10, 2026
The integrated Lei-CNS PBPK-PD model effectively predicts clozapine brain disposition and D2 receptor occupancy in humans.

|Aug 26, 2026
Do Brain Extracellular Fluid Concentrations Predict PET-Inferred Receptor Occupancy in Human CNS? A Mechanistic Model-Based Analysis of Dopamine D2 Receptor Ligands.

|Jun 17, 2026
In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium.

|Feb 02, 2026
Simulation-based assessment of the P-glycoprotein expression-activity relationship shows a drug and system dependency.

Daan W van Valkengoed, Vivi Rottschäfer, Elizabeth C M de Lange

|Feb 08, 2025
Reliability of in vitro data for the mechanistic prediction of brain extracellular fluid pharmacokinetics of P-glycoprotein substrates in vivo; are we scaling correctly?

Daan W van Valkengoed, Makoto Hirasawa, Vivi Rottschäfer

|Jan 08, 2025
Do P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier impact morphine brain distribution?

Berfin Gülave, Ariel Lesmana, Elizabeth Cm de Lange

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Frequent Collaborators

4 joint publications

Jeroen Elassaiss-Schaap

3 joint publications

Daan W van Valkengoed

3 joint publications

J G Coen van Hasselt

3 joint publications

Vivi Rottschäfer