Leslie N Aldrich

17PUBLICATIONS
18CO-AUTHORS
Molecular targetsBiologically active moleculesCharacterisation of biological macromoleculesCell development, proliferation and deathToxicology (incl. clinical toxicology)
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Publications (17)

|Apr 03, 2026
Discovery of Autophagy Modulators that Increase I1061T NPC1 Expression and Promote Cholesterol Efflux in Niemann-Pick Type C Patient-Derived Fibroblasts.

Maryna Salkovski, Andrea Arrieche Suarez, Qiwen Gao

|Mar 19, 2026
Structure-Activity Relationship Studies Enable Optimization of a Small-Molecule Autophagy Activator and Evaluation of Effects on Cell Death Pathways.

Andrew Dobria, Andrea Arrieche Suarez, Thomas Whitmarsh-Everiss

|Feb 16, 2026
Development of a Late-Stage Functionalization Strategy to Access Diverse 3,5-Disubstituted 1,2,4-Thiadiazoles.

Andrew Dobria, Zoe A Petros, Philip Mickel

|Jan 06, 2025
Structure-Activity Relationship Studies of an Autophagy Inhibitor That Targets the ATG14L-Beclin1 Protein-Protein Interaction Reveal Modifications That Improve Potency and Solubility and Maintain Selectivity.

Ryan S Hippman, Qiwen Gao, Andrea Arrieche Suarez

|Dec 09, 2023
Discovery of a Small-Molecule Modulator of the Autophagy-Lysosome Pathway That Targets Lamin A/C and LAMP1, Induces Autophagic Flux, and Affects Lysosome Positioning in Neurons.

Ryan S Hippman, Amanda M Snead, Zoe A Petros

|Aug 29, 2023
Probing the Cytotoxic Signaling Induced by Eupenifeldin in Ovarian Cancer Models.

Amanda C Maldonado, Monica A Haughan, Manead Khin

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Frequent Collaborators

4 joint publications

Melissa A Korkmaz-Vaisys

3 joint publications

Joanna E Burdette

3 joint publications

Andrew Dobria

2 joint publications

Ryan S Hippman