Hans-Georg Lerchen

8PUBLICATIONS
14CO-AUTHORS
Molecular medicineBiomolecular modelling and designApplied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies)Molecular targetsRadiation therapy
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Publications (8)

|Sep 09, 2023
Discovery of VIP236, an αvβ3-Targeted Small-Molecule-Drug Conjugate with Neutrophil Elastase-Mediated Activation of 7-Ethyl Camptothecin Payload for Treatment of Solid Tumors.

Hans-Georg Lerchen, Beatrix Stelte-Ludwig, Melanie Heroult

|Jan 21, 2022
A Small Molecule-Drug Conjugate (SMDC) Consisting of a Modified Camptothecin Payload Linked to an αVß3 Binder for the Treatment of Multiple Cancer Types.

Hans-Georg Lerchen, Beatrix Stelte-Ludwig, Charlotte Kopitz

|Nov 25, 2020
IL3RA-Targeting Antibody-Drug Conjugate BAY-943 with a Kinesin Spindle Protein Inhibitor Payload Shows Efficacy in Preclinical Models of Hematologic Malignancies.

Dennis Kirchhoff, Beatrix Stelte-Ludwig, Hans-Georg Lerchen

|Jul 16, 2020
Tailored Linker Chemistries for the Efficient and Selective Activation of ADCs with KSPi Payloads.

Hans-Georg Lerchen, Beatrix Stelte-Ludwig, Anette Sommer

|Dec 10, 2019
A Selective Carborane-Functionalized Gastrin-Releasing Peptide Receptor Agonist as Boron Delivery Agent for Boron Neutron Capture Therapy.

Paul Hoppenz, Sylvia Els-Heindl, Martin Kellert

|Mar 15, 2019
Antibody-Prodrug Conjugates with KSP Inhibitors and Legumain-Mediated Metabolite Formation.

Hans-Georg Lerchen, Beatrix Stelte-Ludwig, Sandra Berndt

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Frequent Collaborators

3 joint publications

Anette Sommer

2 joint publications

Beatrix Stelte-Ludwig

1 joint publications

André Raposo Moreira Dias

1 joint publications

Arianna Pina