Focco van den Akker

10PUBLICATIONS
16CO-AUTHORS
Medical infection agents (incl. prions)Industrial molecular engineering of nucleic acids and proteinsCheminformatics and quantitative structure-activity relationshipsMedical bacteriologyBacteriology
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Publications (10)

|Jun 12, 2025
Structure and mechanism of taniborbactam inhibition of the cefepime-hydrolyzing, partial R2-loop deletion Pseudomonas-derived cephalosporinase variant PDC-88.

Andrew R Mack, Vijay Kumar, Christopher R Bethel

|Feb 21, 2024
Structural insights into peptidoglycan glycosidase EtgA binding to the inner rod protein EscI of the type III secretion system via a designed EscI-EtgA fusion protein.

J Boorman, X Zeng, J Lin

|Oct 18, 2023
Natural protein engineering in the Ω-loop: the role of Y221 in ceftazidime and ceftolozane resistance in Pseudomonas-derived cephalosporinase.

Andrew R Mack, Vijay Kumar, Magdalena A Taracila

|Sep 26, 2023
Exploring avibactam and relebactam inhibition of Klebsiella pneumoniae carbapenemase D179N variant: role of the Ω loop-held deacylation water.

T A Alsenani, S L Viviani, K M Papp-Wallace

|Mar 28, 2022
Structural Characterization of the D179N and D179Y Variants of KPC-2 β-Lactamase: Ω-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam.

T A Alsenani, S L Viviani, V Kumar

|Oct 15, 2021
Structural analysis of the boronic acid β-lactamase inhibitor vaborbactam binding to Pseudomonas aeruginosa penicillin-binding protein 3.

Vijay Kumar, Samantha L Viviani, Jeeda Ismail

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Frequent Collaborators

5 joint publications

Krisztina M Papp-Wallace

5 joint publications

Robert A Bonomo

3 joint publications

Vijay Kumar

2 joint publications

Andrew R Mack