Lesley Kane
4PUBLICATIONS
59CO-AUTHORS
Get your video featured.
Publish with JoVEGet your video featured.
Publish with JoVE
Publications (4)
Sort by Publication Date:
|Aug 18, 2025
Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial.Brittany N Flores, Seungyoon B Yu, Isaac V Cohen
|Sep 17, 2024
DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response.Ernie Yulyaningsih, Jung H Suh, Melania Fanok
|Aug 14, 2024
Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier.Scarlett J Barker, Mai B Thayer, Chaeyoung Kim
|May 29, 2020
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys.Mihalis S Kariolis, Robert C Wells, Jennifer A Getz
Pageof 1
Frequent Collaborators
3 joint publications
Joseph W Lewcock
2 joint publications
Y Zuchero
2 joint publications
Thomas Sandmann
2 joint publications
Robert G Thorne
2 joint publications
Mark S Dennis
2 joint publications
Raymond Tong
2 joint publications
Robert C Wells
2 joint publications
Michelle Pizzo
2 joint publications
Kylie S Chew
2 joint publications
Cathal S Mahon
