Christian Landles

15PUBLICATIONS
75CO-AUTHORS
Molecular targetsCardiology (incl. cardiovascular diseases)Critical heritage, museum and archive studiesNeurogeneticsEpigenetics (incl. genome methylation and epigenomics)
Featured researcher

Get your video featured.

JoVEPublish with JoVE
Journal

Publications (15)

|Oct 22, 2026
Cas9 nickase-mediated contraction of CAG/CTG repeats is associated with phenotypic improvements in a Huntington's disease mouse model.

|Aug 30, 2026
Human-specific sequence features in HTT exon 1 promote toxic misprocessing via splicing factor SRSF7.

|Aug 12, 2026
Blocking somatic repeat expansion and lowering huntingtin by RNAi synergize to attenuate Huntington's disease pathogenesis in mice.

|Aug 04, 2026
Enhancing the detection of HTT1a with neoepitope antibodies in mouse models of Huntington's disease.

|Mar 18, 2026
Lowering the HTT1a transcript as an effective therapy for Huntington's disease in a knockin mouse model.

Aikaterini Smaragdi Papadopoulou, Julia Alterman, Christian Landles

|Mar 18, 2026
Selective targeting of mutant huntingtin intron 1 improves rescue provided by antisense oligonucleotides in Huntington's disease mice.

Robert M Bragg, Christian Landles, Edward J Smith

Pageof 3

Frequent Collaborators

14 joint publications

Georgina Osborne

14 joint publications

Gillian P Bates

5 joint publications

Jemima Phillips

3 joint publications

Edward J Smith