Edward P O'Brien

28PUBLICATIONS
34CO-AUTHORS
Life historiesStructural biology (incl. macromolecular modelling)Nanoelectromechanical systemsLasers and quantum electronicsProteomics and intermolecular interactions (excl. medical proteomics)
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Publications (28)

|Aug 05, 2026
Synonymous mutations in essential genes infrequently produce fitness effects in human cell lines.

|Jan 06, 2026
Phosphoglycerate Kinase Can Adopt Topologically Misfolded Forms That Are More Stable Than Its Native State.

Yingzi Xia, Barbara T Amann, Richard E Gillilan

|Dec 12, 2025
A widespread protein misfolding mechanism is differentially rescued in vitro by chaperones based on gene essentiality.

Ian Sitarik, Quyen V Vu, Justin Petucci

|Aug 08, 2025
Non-native entanglement protein misfolding observed in all-atom simulations and supported by experimental structural ensembles.

Quyen V Vu, Ian Sitarik, Yang Jiang

|May 10, 2025
Proteome-wide determinants of co-translational chaperone binding in bacteria.

Carla Verónica Galmozzi, Frank Tippmann, Florian Wruck

|May 03, 2025
Noncovalent Lasso Entanglements are Common in Experimentally Derived Intrinsically Disordered Protein Ensembles and Strongly Influenced by Protein Length and Charge.

Quyen V Vu, Ian Sitarik, Mai Suan Li

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Frequent Collaborators

12 joint publications

Yang Jiang

10 joint publications

Mai Suan Li

8 joint publications

Quyen V Vu

5 joint publications

Stephen D Fried