Richard J Spears

8PUBLICATIONS
24CO-AUTHORS
Proteins and peptidesGlycoconjugatesOrganic chemical synthesisCatalysis and mechanisms of reactionsOrganometallic chemistry
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Publications (8)

|Jun 07, 2024
Chemo- and regio-selective differential modification of native cysteines on an antibody via the use of dehydroalanine forming reagents.

Steven Y Yap, Tobias Butcher, Richard J Spears

|Jan 25, 2024
Cross aldol OPAL bioconjugation outcompetes intramolecular hemiaminal cyclisation of proline adjacent N-terminal α-oxo aldehydes at acidic pH.

Afzaal Tufail, Saeed Akkad, Natasha E Hatton

|Dec 11, 2023
Use of pyridazinediones for tuneable and reversible covalent cysteine modification applied to peptides, proteins and hydrogels.

Léa N C Rochet, Calise Bahou, Jonathan P Wojciechowski

|Aug 17, 2022
Functionalisation of ethereal-based saturated heterocycles with concomitant aerobic C-H activation and C-C bond formation.

Nehaal Ahmed, Richard J Spears, Tom D Sheppard

|Apr 08, 2022
Unearthing the unique stability of thiophosphonium-C-terminal cysteine adducts on peptides and proteins.

Richard J Spears, Alina Chrzastek, Steven Y Yap

|Nov 08, 2021
A novel thiol-labile cysteine protecting group for peptide synthesis based on a pyridazinedione (PD) scaffold.

Richard J Spears, Clíona McMahon, Monika Shamsabadi

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Frequent Collaborators

5 joint publications

Vijay Chudasama

4 joint publications

James R Baker

2 joint publications

Steven Y Yap

2 joint publications

Tessa Keenan