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Mark Cushman

6PUBLICATIONS

7CO-AUTHORS

Cheminformatics and quantitative structure-activity relationshipsMolecular targetsToxicology (incl. clinical toxicology)

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Publications (6)

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|Apr 26, 2024

Design, Synthesis, and Investigation of the Pharmacokinetics and Anticancer Activities of Indenoisoquinoline Derivatives That Stabilize the G-Quadruplex in the <i>MYC</i> Promoter and Inhibit Topoisomerase I.

Yichen Han, Adam Buric, Venkat Chintareddy

|Dec 08, 2021

Design and Synthesis of Indenoisoquinolines Targeting Topoisomerase I and Other Biological Macromolecules for Cancer Chemotherapy.

Mark Cushman

|Jul 09, 2019

Indenoisoquinoline Topoisomerase Inhibitors Strongly Bind and Stabilize the <i>MYC</i> Promoter G-Quadruplex and Downregulate <i>MYC</i>.

Kai-Bo Wang, Mohamed S A Elsayed, Guanhui Wu

|Nov 22, 2018

Application of Sequential Palladium Catalysis for the Discovery of Janus Kinase Inhibitors in the Benzo[ c]pyrrolo[2,3- h][1,6]naphthyridin-5-one (BPN) Series.

Mohamed S A Elsayed, Jeffery J Nielsen, Sungtae Park

|Jun 29, 2017

Design and Synthesis of Chlorinated and Fluorinated 7-Azaindenoisoquinolines as Potent Cytotoxic Anticancer Agents That Inhibit Topoisomerase I.

Mohamed S A Elsayed, Yafan Su, Ping Wang

|Apr 19, 2017

Synthesis and Biological Evaluation of the First Triple Inhibitors of Human Topoisomerase 1, Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), and Tyrosyl-DNA Phosphodiesterase 2 (Tdp2).

Ping Wang, Mohamed S A Elsayed, Caroline B Plescia

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Frequent Collaborators

2 joint publications

Mohamed S A Elsayed

2 joint publications

Danzhou Yang

1 joint publications

Philip S Low

1 joint publications

Kai-Bo Wang

1 joint publications

Nanjie Deng

1 joint publications

Yichen Han

1 joint publications

Jonathan Dickerhoff

Frequent Collaborators

2 joint publications

Mohamed S A Elsayed

2 joint publications

Danzhou Yang

1 joint publications

Philip S Low

1 joint publications

Kai-Bo Wang

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