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Michy P Kelly

7PUBLICATIONS

2CO-AUTHORS

Psychology of ageingProteins and peptidesEpigenetics (incl. genome methylation and epigenomics)Memory and attentionCentral nervous system

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Publications (7)

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|Jun 25, 2025

Age-Related Increases in PDE11A4 Protein Expression Trigger Liquid-Liquid Phase Separation (LLPS) of the Enzyme That Can Be Reversed by PDE11A4 Small Molecule Inhibitors.

Elvis Amurrio, Janvi H Patel, Marie Danaher

|Jun 06, 2025

Molecular mechanisms regulating PDE11A4 age-related liquid-liquid phase separation (LLPS) and its reversal by selective, potent and orally-available PDE11A4 small molecule inhibitors both <i>in vitro</i> and <i>in vivo</i>.

E Amurrio, J Patel, M Danaher

|Dec 22, 2023

The Sleep Quality- and Myopia-Linked PDE11A-Y727C Variant Impacts Neural Physiology by Reducing Catalytic Activity and Altering Subcellular Compartmentalization of the Enzyme.

Irina Sbornova, Emilie van der Sande, Snezana Milosavljevic

|Sep 08, 2022

Conserved age-related increases in hippocampal PDE11A4 cause unexpected proteinopathies and cognitive decline of social associative memories.

Katy Pilarzyk, Latarsha Porcher, William R Capell

|Sep 23, 2021

Aging triggers an upregulation of a multitude of cytokines in the male and especially the female rodent hippocampus but more discrete changes in other brain regions.

Latarsha Porcher, Sophie Bruckmeier, Steven D Burbano

|Jul 29, 2021

A genetic basis for friendship? Homophily for membrane-associated PDE11A-cAMP-CREB signaling in CA1 of hippocampus dictates mutual social preference in male and female mice.

Abigail J Smith, Reagan Farmer, Katy Pilarzyk

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Frequent Collaborators

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Gonzalo S Tejeda

1 joint publications

Katy Pilarzyk

Frequent Collaborators

1 joint publications

Gonzalo S Tejeda

1 joint publications

Katy Pilarzyk

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