Lei Guo

6PUBLICATIONS
8CO-AUTHORS
Toxicology (incl. clinical toxicology)Gene and molecular therapyMolecular targetsProteins and peptidesEnzymes
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Journal

Publications (6)

|Nov 21, 2025
Structure-Based Optimization of Imidazopyridine Derivatives as Selective and Orally Bioavailable Phosphodiesterase 10A Inhibitors with Reduced Blood-Brain Barrier Penetration for the Treatment of Idiopathic Pulmonary Fibrosis.

Fengcai Zhang, Han Yuan, Siqi Yao

|Sep 11, 2025
Discovery of a Novel COS/H<sub>2</sub>S-Donor Hybridized sGC Stimulator for Alleviating Isoproterenol-Induced Myocardial Fibrosis.

Yi Yang, Jiafei Wu, Gongyun He

|Jan 16, 2025
Inhalable Carbonyl Sulfide Donor-Hybridized Selective Phosphodiesterase 10A Inhibitor for Treating Idiopathic Pulmonary Fibrosis by Inhibiting Tumor Growth Factor-β Signaling and Activating the cAMP/Protein Kinase A/cAMP Response Element-Binding Protein (CREB)/p53 Axis.

Quan Wang, Xinyue Liu, Han Yuan

|May 02, 2022
Discovery of catalytic-site-fluorescent probes for tracing phosphodiesterase 5 in living cells.

Meiying Qiu, Deyan Wu, Yi-You Huang

|May 06, 2021
Discovery of Highly Specific Catalytic-Site-Targeting Fluorescent Probes for Detecting Lysosomal PDE10A in Living Cells.

Yuqi Gao, Ju Huang, Qian Zhou

|Feb 28, 2020
Discovery and Optimization of Chromone Derivatives as Novel Selective Phosphodiesterase 10 Inhibitors.

Yan-Fa Yu, Chen Zhang, Yi-You Huang

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Frequent Collaborators

3 joint publications

Hai-Bin Luo

2 joint publications

Yi-You Huang

2 joint publications

Deyan Wu

1 joint publications

Chen Zhang